PMID- 37754224
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 45
IP  - 9
DP  - 2023 Aug 22
TI  - Immunomodulatory and Antioxidant Properties of Ipomoea batatas Flour and Extracts 
      Obtained by Green Extraction.
PG  - 6967-6985
LID - 10.3390/cimb45090440 [doi]
AB  - Sweet potato (SP), Ipomoea batatas Lam, belongs to the Convolvulaceae family. It 
      produces edible storage roots. Currently, orange varieties contribute to 
      improving food systems and managing vitamin A deficiency. Processing of this food 
      crop into flour allows better conservation. However, nutrition health data 
      regarding SP flour obtained by green extraction remains scarce. In this study, we 
      therefore explored its phytochemistry and its associated bioactivity potential 
      for human health. We analyzed the nutritional composition of orange flesh sweet 
      potato (OFSP) flour and assessed the antioxidant (free radical scavenging) and 
      immunomodulatory (on inflammatory murine macrophages) properties of the extract. 
      More specifically, we measured the impact of OFSP flour extract on mediators such 
      as Nitric Oxide (NO) and the production of pro-inflammatory cytokines such as 
      Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-alpha), Monocyte 
      Chemoattractant Protein-1 (MCP-1), and Prostaglandin-E2 (PGE-2). Our results 
      indicated significant fiber, mineral, beta-carotene, and polyphenols content in 
      the extracts, and antioxidant and immunomodulatory bioactivities were also 
      demonstrated with a concentration-dependent inhibition of cytokine production. 
      Taken together, our results suggest that Ipomoea batatas flour could, in addition 
      to being a good source of energy and beta-carotene provitamin A, constitute a 
      food of interest for the prophylaxis of metabolic diseases associated with an 
      underlying low-grade inflammatory state.
FAU - Boukhers, Imane
AU  - Boukhers I
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
FAU - Morel, Sylvie
AU  - Morel S
AD  - Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, CNRS-Universite de 
      Montpellier-Universite Paul-Valery Montpellier-EPHE-IRD, 34093 Montpellier, 
      France.
FAU - Kongolo, Joelle
AU  - Kongolo J
AUID- ORCID: 0000-0002-1045-0609
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
FAU - Domingo, Romain
AU  - Domingo R
AUID- ORCID: 0000-0002-6372-4925
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
FAU - Servent, Adrien
AU  - Servent A
AUID- ORCID: 0000-0002-9670-6707
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
FAU - Ollier, Lea
AU  - Ollier L
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
FAU - Kodja, Hippolyte
AU  - Kodja H
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
FAU - Petit, Thomas
AU  - Petit T
AUID- ORCID: 0000-0002-3450-5782
AD  - Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments 
      (LCSNSA), Universite de La Reunion, 34093 Sainte-Clotilde, France.
FAU - Poucheret, Patrick
AU  - Poucheret P
AUID- ORCID: 0000-0003-1553-5502
AD  - Qualisud, Univ Montpellier, Avignon Universite, CIRAD, Institut Agro, IRD, 
      Universite de La Reunion, 97400 Montpellier, France.
LA  - eng
GR  - the FEDER grant: Feder European Project RAFALE D2016009986-AAP-RDI 2015-1a - 
      Action 1.09 - Synergie Number: RE0002581/European Union/
PT  - Journal Article
DEP - 20230822
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
PMC - PMC10529725
OTO - NOTNLM
OT  - anti-inflammatory activity
OT  - antioxidant activity
OT  - beta-carotene
OT  - chronic metabolic diseases
OT  - orange flesh sweet potato flour
OT  - phenolic compounds
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/09/27 12:42
MHDA- 2023/09/27 12:43
PMCR- 2023/08/22
CRDT- 2023/09/27 08:53
PHST- 2023/08/04 00:00 [received]
PHST- 2023/08/18 00:00 [revised]
PHST- 2023/08/21 00:00 [accepted]
PHST- 2023/09/27 12:43 [medline]
PHST- 2023/09/27 12:42 [pubmed]
PHST- 2023/09/27 08:53 [entrez]
PHST- 2023/08/22 00:00 [pmc-release]
AID - cimb45090440 [pii]
AID - cimb-45-00440 [pii]
AID - 10.3390/cimb45090440 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2023 Aug 22;45(9):6967-6985. doi: 10.3390/cimb45090440.