PMID- 37755054
OWN - NLM
STAT- Publisher
LR  - 20231003
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 9
IP  - 9
DP  - 2023 Sep 20
TI  - Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in 
      the Endemic Area of Rio de Janeiro, Brazil.
LID - 10.3390/jof9090946 [doi]
LID - 946
AB  - Paracoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. 
      Most cases occur in Brazil. It is classified as PCM infection and PCM disease and 
      is subdivided into chronic (adult type) or acute (juvenile type) disease, with 
      the latter being less frequent and more severe. In 2016, we reported an increase 
      in the numbers of patients diagnosed with acute PCM after a highway's 
      construction. We conducted a study at INI-Fiocruz, a reference center for 
      infectious diseases, including endemic mycoses, in Rio de Janeiro, Brazil, aiming 
      to deepen the analysis of this new clinical and epidemiological profile of PCM. 
      The authors developed a retrospective study including 170 patients diagnosed with 
      PCM between 2010 and 2019. There was an increase in the number of atypical and 
      severe forms, starting in 2014. In subsequent years, we detected a higher 
      incidence of adverse outcomes with patients requiring more hospitalizations and 
      an increased mortality rate. We estimate that PCM has become more severe 
      throughout the Rio de Janeiro state, affecting a greater number of young 
      individuals and leading to a greater number of and longer hospitalizations. 
      Surveillance measures and close monitoring of future notification data in the 
      state, with emphasis on children, adolescents, and young adults are necessary for 
      a better understanding of the perpetuation of this public health challenge.
FAU - Falcao, Eduardo Mastrangelo Marinho
AU  - Falcao EMM
AUID- ORCID: 0000-0003-2118-653X
AD  - Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas 
      National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, 
      Brazil.
FAU - Freitas, Dayvison Francis Saraiva
AU  - Freitas DFS
AUID- ORCID: 0000-0003-2039-2438
AD  - Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas 
      National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, 
      Brazil.
FAU - Coutinho, Ziadir Francisco
AU  - Coutinho ZF
AD  - Germano Sinval Faria School Health Center, Sergio Arouca National School of 
      Public Health, Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - Quintella, Leonardo Pereira
AU  - Quintella LP
AUID- ORCID: 0000-0002-2076-8776
AD  - Anatomical Pathology Service, Evandro Chagas National Institute of Infectious 
      Diseases, Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - Muniz, Mauro de Medeiros
AU  - Muniz MM
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - Almeida-Paes, Rodrigo
AU  - Almeida-Paes R
AUID- ORCID: 0000-0002-6639-6058
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - Zancope-Oliveira, Rosely Maria
AU  - Zancope-Oliveira RM
AD  - Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, 
      Fiocruz, Rio de Janeiro 21040-900, Brazil.
FAU - de Macedo, Priscila Marques
AU  - de Macedo PM
AUID- ORCID: 0000-0002-6900-9703
AD  - Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas 
      National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, 
      Brazil.
FAU - do Valle, Antonio Carlos Francesconi
AU  - do Valle ACF
AD  - Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas 
      National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, 
      Brazil.
LA  - eng
GR  - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
DEP - 20230920
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC10532664
OTO - NOTNLM
OT  - Paracoccidioides
OT  - mycoses
OT  - neglected diseases
OT  - paracoccidioidomycosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/27 12:41
MHDA- 2023/09/27 12:41
PMCR- 2023/09/20
CRDT- 2023/09/27 09:24
PHST- 2023/08/16 00:00 [received]
PHST- 2023/09/13 00:00 [revised]
PHST- 2023/09/18 00:00 [accepted]
PHST- 2023/09/27 12:41 [medline]
PHST- 2023/09/27 12:41 [pubmed]
PHST- 2023/09/27 09:24 [entrez]
PHST- 2023/09/20 00:00 [pmc-release]
AID - jof9090946 [pii]
AID - jof-09-00946 [pii]
AID - 10.3390/jof9090946 [doi]
PST - epublish
SO  - J Fungi (Basel). 2023 Sep 20;9(9):946. doi: 10.3390/jof9090946.