PMID- 37755297
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 13
IP  - 9
DP  - 2023 Sep 15
TI  - Unlocking the Potential: Amino Acids' Role in Predicting and Exploring 
      Therapeutic Avenues for Type 2 Diabetes Mellitus.
LID - 10.3390/metabo13091017 [doi]
LID - 1017
AB  - Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), imposes a 
      significant global burden with adverse clinical outcomes and escalating 
      healthcare expenditures. Early identification of biomarkers can facilitate better 
      screening, earlier diagnosis, and the prevention of diabetes. However, current 
      clinical predictors often fail to detect abnormalities during the prediabetic 
      state. Emerging studies have identified specific amino acids as potential 
      biomarkers for predicting the onset and progression of diabetes. Understanding 
      the underlying pathophysiological mechanisms can offer valuable insights into 
      disease prevention and therapeutic interventions. This review provides a 
      comprehensive summary of evidence supporting the use of amino acids and 
      metabolites as clinical biomarkers for insulin resistance and diabetes. We 
      discuss promising combinations of amino acids, including branched-chain amino 
      acids, aromatic amino acids, glycine, asparagine and aspartate, in the prediction 
      of T2DM. Furthermore, we delve into the mechanisms involving various signaling 
      pathways and the metabolism underlying the role of amino acids in disease 
      development. Finally, we highlight the potential of targeting predictive amino 
      acids for preventive and therapeutic interventions, aiming to inspire further 
      clinical investigations and mitigate the progression of T2DM, particularly in the 
      prediabetic stage.
FAU - Ding, Yilan
AU  - Ding Y
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai 200025, China.
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commission of the PR China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 
      200025, China.
FAU - Wang, Shuangyuan
AU  - Wang S
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai 200025, China.
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commission of the PR China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 
      200025, China.
FAU - Lu, Jieli
AU  - Lu J
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai 200025, China.
AD  - Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, 
      Key Laboratory for Endocrine and Metabolic Diseases of the National Health 
      Commission of the PR China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 
      200025, China.
LA  - eng
GR  - grant nos. 81970691/the National Natural Science Foundation of China/
GR  - grant nos. 20Y11905100/Innovative research team of high-level local universities 
      in Shanghai, Science and Technology Committee of Shanghai/
GR  - grant nos. 19MC1910100/Innovative research team of high-level local universities 
      in Shanghai, Science and Technology Committee of Shanghai/
GR  - grant nos. 20224Y0087/Clinical Research Project of Shanghai Municipal Health 
      Commission/
PT  - Journal Article
PT  - Review
DEP - 20230915
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC10535527
OTO - NOTNLM
OT  - amino acids
OT  - intervention
OT  - mechanism
OT  - prediction
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/27 12:42
MHDA- 2023/09/27 12:43
PMCR- 2023/09/15
CRDT- 2023/09/27 09:55
PHST- 2023/08/10 00:00 [received]
PHST- 2023/09/08 00:00 [revised]
PHST- 2023/09/13 00:00 [accepted]
PHST- 2023/09/27 12:43 [medline]
PHST- 2023/09/27 12:42 [pubmed]
PHST- 2023/09/27 09:55 [entrez]
PHST- 2023/09/15 00:00 [pmc-release]
AID - metabo13091017 [pii]
AID - metabolites-13-01017 [pii]
AID - 10.3390/metabo13091017 [doi]
PST - epublish
SO  - Metabolites. 2023 Sep 15;13(9):1017. doi: 10.3390/metabo13091017.