PMID- 37755654
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231129
IS  - 1535-1645 (Electronic)
IS  - 1523-3812 (Print)
IS  - 1523-3812 (Linking)
VI  - 25
IP  - 11
DP  - 2023 Nov
TI  - Recent Updates on Predicting Conversion in Youth at Clinical High Risk for 
      Psychosis.
PG  - 683-698
LID - 10.1007/s11920-023-01456-2 [doi]
AB  - PURPOSE OF REVIEW: This review highlights recent advances in the prediction and 
      treatment of psychotic conversion. Over the past 25 years, research into the 
      prodromal phase of psychotic illness has expanded with the promise of early 
      identification of individuals at clinical high risk (CHR) for psychosis who are 
      likely to convert to psychosis. RECENT FINDINGS: Meta-analyses highlight 
      conversion rates between 20 and 30% within 2-3 years using existing clinical 
      criteria while research into more specific risk factors, biomarkers, and 
      refinement of psychosis risk calculators has exploded, improving our ability to 
      predict psychotic conversion with greater accuracy. Recent studies highlight risk 
      factors and biomarkers likely to contribute to earlier identification and provide 
      insight into neurodevelopmental abnormalities, CHR subtypes, and interventions 
      that can target specific risk profiles linked to neural mechanisms. Ongoing 
      initiatives that assess longer-term (> 5-10 years) outcome of CHR participants 
      can provide valuable information about predictors of later conversion and 
      diagnostic outcomes while large-scale international biomarker studies provide 
      hope for precision intervention that will alter the course of early psychosis 
      globally.
CI  - (c) 2023. The Author(s).
FAU - Caballero, Noe
AU  - Caballero N
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La 
      Jolla, CA, 92093-0810, USA.
FAU - Machiraju, Siddharth
AU  - Machiraju S
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La 
      Jolla, CA, 92093-0810, USA.
FAU - Diomino, Anthony
AU  - Diomino A
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La 
      Jolla, CA, 92093-0810, USA.
FAU - Kennedy, Leda
AU  - Kennedy L
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La 
      Jolla, CA, 92093-0810, USA.
FAU - Kadivar, Armita
AU  - Kadivar A
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La 
      Jolla, CA, 92093-0810, USA.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AUID- ORCID: 0000-0002-5952-4605
AD  - Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La 
      Jolla, CA, 92093-0810, USA. kcadenhead@health.ucsd.edu.
LA  - eng
GR  - R01 MH105243/MH/NIMH NIH HHS/United States
GR  - R01 MH123641/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
GR  - U01 MH124639/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20230927
PL  - United States
TA  - Curr Psychiatry Rep
JT  - Current psychiatry reports
JID - 100888960
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - *Psychotic Disorders/diagnosis/therapy
MH  - Risk Factors
MH  - Longitudinal Studies
MH  - Risk Assessment
MH  - Biomarkers
PMC - PMC10654175
OTO - NOTNLM
OT  - Biomarkers
OT  - Clinical high risk
OT  - Conversion
OT  - Prodome
OT  - Psychosis
OT  - Treatment
COIS- The authors declare no competing interests.
EDAT- 2023/09/27 12:41
MHDA- 2023/11/27 12:43
PMCR- 2023/09/27
CRDT- 2023/09/27 11:12
PHST- 2023/09/05 00:00 [accepted]
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/09/27 12:41 [pubmed]
PHST- 2023/09/27 11:12 [entrez]
PHST- 2023/09/27 00:00 [pmc-release]
AID - 10.1007/s11920-023-01456-2 [pii]
AID - 1456 [pii]
AID - 10.1007/s11920-023-01456-2 [doi]
PST - ppublish
SO  - Curr Psychiatry Rep. 2023 Nov;25(11):683-698. doi: 10.1007/s11920-023-01456-2. 
      Epub 2023 Sep 27.