PMID- 37755740
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 11
IP  - 9
DP  - 2023 Aug 25
TI  - Short-Term Exposure to PM(2.5) and O(3) Impairs Liver Function in HIV/AIDS 
      Patients: Evidence from a Repeated Measurements Study.
LID - 10.3390/toxics11090729 [doi]
LID - 729
AB  - Studies investigating the relationship between ambient air pollutants and liver 
      function are scarce. Our objective was to examine the associations of acute 
      exposure to PM(2.5) and O(3) with levels of hepatic enzymes in people living with 
      HIV/AIDS (PWHA). Our study involved 163 PWHA, who were evaluated for serum 
      hepatic enzymes up to four times within a year. We extracted daily average 
      concentrations of PM(2.5), PM(2.5) components, and O(3) for each participant, 
      based on their residential address, using the Tracking of Air Pollution in China 
      database. Linear mixed-effect models were utilized to assess the associations of 
      acute exposure to PM(2.5) and O(3) with hepatic enzymes. Weighted quantile sum 
      regression models were employed to identify the major constituents of PM(2.5) 
      that affect hepatic enzymes. The percent change of aspartate aminotransferase 
      (AST) concentration was positively correlated with a 10 microg/m(3) increase in 
      PM(2.5), ranging from 1.92 (95% CI: 3.13 to 4.38) to 6.09 (95% CI: 9.25 to 
      12.38), with the largest effect observed at lag06. Additionally, acute O(3) 
      exposure was related to increased levels of alanine aminotransferase (ALT), AST, 
      and alkaline phosphatase (ALP) concentrations. Co-exposure to high levels of 
      PM(2.5) and O(3) had an antagonistic effect on the elevation of AST. Further 
      analysis revealed that SO(4)(2-) and BC were major contributors to elevated AST 
      concentration due to PM(2.5) constituents. A stronger association was found 
      between O(3) exposure and ALT concentration in female PWHA. Our study found that 
      short-term exposure to PM(2.5) and O(3) was associated with increased levels of 
      hepatic enzymes, indicating that PM(2.5) and O(3) exposure may contribute to 
      hepatocellular injury in PWHA. Our study also found that PWHA may be more 
      vulnerable to air pollution than the general population. These findings highlight 
      the relationship between air pollutants and liver function in PWHA, providing a 
      scientific basis for the implementation of measures to protect susceptible 
      populations from the adverse effects of air pollution. A reduction in the burning 
      of fossil fuels and reduced exposure to air pollutants may be effective hazard 
      reduction approaches.
FAU - Ma, Hongfei
AU  - Ma H
AD  - Wuhan Center for Disease Control and Prevention, 288# Machang Road, Wuhan 430024, 
      China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Qingshan District Center for Disease Control and Prevention, 4# Yangang Road, 
      Wuhan 430070, China.
FAU - Liang, Wei
AU  - Liang W
AUID- ORCID: 0000-0002-4725-9605
AD  - Department of Global Health, School of Public Health, Wuhan University, 115# 
      Donghu Road, Wuhan 430071, China.
FAU - Han, Aojing
AU  - Han A
AD  - Department of Global Health, School of Public Health, Wuhan University, 115# 
      Donghu Road, Wuhan 430071, China.
FAU - Xie, Nianhua
AU  - Xie N
AD  - Wuhan Center for Disease Control and Prevention, 288# Machang Road, Wuhan 430024, 
      China.
FAU - Xiang, Hao
AU  - Xiang H
AUID- ORCID: 0000-0003-0902-0115
AD  - Department of Global Health, School of Public Health, Wuhan University, 115# 
      Donghu Road, Wuhan 430071, China.
FAU - Wang, Xia
AU  - Wang X
AD  - Wuhan Center for Disease Control and Prevention, 288# Machang Road, Wuhan 430024, 
      China.
LA  - eng
GR  - WY22M02/Wuhan Municipal Health Commission/
PT  - Journal Article
DEP - 20230825
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC10537338
OTO - NOTNLM
OT  - HIV/AIDS
OT  - O3
OT  - PM2.5
OT  - constituents
OT  - hepatic enzymes
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/27 12:42
MHDA- 2023/09/27 12:43
PMCR- 2023/08/25
CRDT- 2023/09/27 11:33
PHST- 2023/07/20 00:00 [received]
PHST- 2023/08/11 00:00 [revised]
PHST- 2023/08/23 00:00 [accepted]
PHST- 2023/09/27 12:43 [medline]
PHST- 2023/09/27 12:42 [pubmed]
PHST- 2023/09/27 11:33 [entrez]
PHST- 2023/08/25 00:00 [pmc-release]
AID - toxics11090729 [pii]
AID - toxics-11-00729 [pii]
AID - 10.3390/toxics11090729 [doi]
PST - epublish
SO  - Toxics. 2023 Aug 25;11(9):729. doi: 10.3390/toxics11090729.