PMID- 37758787
OWN - NLM
STAT- MEDLINE
DCOM- 20230929
LR  - 20231123
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Sep 27
TI  - Risk factors of severe hypoglycemia among patients with type 2 diabetes mellitus 
      in outpatient clinic of tertiary hospital in Indonesia.
PG  - 16259
LID - 10.1038/s41598-023-43459-2 [doi]
LID - 16259
AB  - This study aimed to describe risk factors of severe hypoglycemia in type 2 
      diabetes mellitus (T2DM) patients in a tertiary care hospital in Indonesia. This 
      study was a retrospective cohort study in the Endocrinology Outpatient Clinic of 
      Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia. All 
      subjects more than 18 years old who had been visiting the clinic for at least a 
      year were included. Subjects were interviewed whether they had any severe 
      hypoglycemia events within the past year, while data on risk factor variables of 
      severe hypoglycemia was taken from medical records one year before data 
      collection. We recruited 291 subjects, among whom 25.4% suffered at least one 
      episode of severe hypoglycemia within one year. History of severe hypoglycemia 
      (OR 5.864, p </= 0.001), eGFR less than 60 mL/min/1.73m(2) (OR 1.976, p = 0.028), 
      and insulin use (OR 2.257, p = 0.021) were associated with increased risk of 
      severe hypoglycemia. In conclusion, history of previous severe hypoglycemia, eGFR 
      less than 60 mL/min/1.73m(2), and insulin use were associated with severe 
      hypoglycemia.
CI  - (c) 2023. Springer Nature Limited.
FAU - Yunir, Em
AU  - Yunir E
AUID- ORCID: 0000-0002-2004-9050
AD  - Division of Endocrinology, Metabolism, and Diabetes, Department of Internal 
      Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine 
      Universitas Indonesia, Jakarta, Indonesia. e.yunir@ui.ac.id.
AD  - Metabolic Disorder, Cardiovascular and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine Universitas Indonesia, 
      Jakarta, Indonesia. e.yunir@ui.ac.id.
FAU - Nugraha, Antonius R A
AU  - Nugraha ARA
AD  - Department of Internal Medicine, Dr. Cipto Mangunkusumo National General 
      Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
FAU - Rosana, Martha
AU  - Rosana M
AUID- ORCID: 0000-0002-2904-6171
AD  - Division of Endocrinology, Metabolism, and Diabetes, Department of Internal 
      Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine 
      Universitas Indonesia, Jakarta, Indonesia.
AD  - Metabolic Disorder, Cardiovascular and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine Universitas Indonesia, 
      Jakarta, Indonesia.
FAU - Kurniawan, Juferdy
AU  - Kurniawan J
AD  - Clinical Epidemiological Unit, Department of Internal Medicine, Dr. Cipto 
      Mangunkusumo National General Hospital, Jakarta, Indonesia.
AD  - Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto 
      Mangunkusumo National General Hospital, Faculty of Medicine Universitas 
      Indonesia, Jakarta, Indonesia.
FAU - Iswati, Eni
AU  - Iswati E
AUID- ORCID: 0000-0003-4975-3647
AD  - Division of Endocrinology, Metabolism, and Diabetes, Department of Internal 
      Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine 
      Universitas Indonesia, Jakarta, Indonesia.
FAU - Sarumpaet, Angela
AU  - Sarumpaet A
AUID- ORCID: 0000-0003-1245-6542
AD  - Division of Endocrinology, Metabolism, and Diabetes, Department of Internal 
      Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine 
      Universitas Indonesia, Jakarta, Indonesia.
FAU - Tarigan, Tri Juli Edi
AU  - Tarigan TJE
AUID- ORCID: 0000-0001-6086-700X
AD  - Division of Endocrinology, Metabolism, and Diabetes, Department of Internal 
      Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine 
      Universitas Indonesia, Jakarta, Indonesia.
AD  - Metabolic Disorder, Cardiovascular and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine Universitas Indonesia, 
      Jakarta, Indonesia.
FAU - Tahapary, Dicky L
AU  - Tahapary DL
AUID- ORCID: 0000-0002-4048-5159
AD  - Division of Endocrinology, Metabolism, and Diabetes, Department of Internal 
      Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine 
      Universitas Indonesia, Jakarta, Indonesia.
AD  - Metabolic Disorder, Cardiovascular and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine Universitas Indonesia, 
      Jakarta, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230927
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Insulins)
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Tertiary Care Centers
MH  - Indonesia/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Ambulatory Care Facilities
MH  - *Hypoglycemia/epidemiology
MH  - *Insulins
PMC - PMC10533826
COIS- The authors declare no competing interests.
EDAT- 2023/09/28 00:42
MHDA- 2023/09/29 06:44
PMCR- 2023/09/27
CRDT- 2023/09/27 23:22
PHST- 2022/01/05 00:00 [received]
PHST- 2023/09/24 00:00 [accepted]
PHST- 2023/09/29 06:44 [medline]
PHST- 2023/09/28 00:42 [pubmed]
PHST- 2023/09/27 23:22 [entrez]
PHST- 2023/09/27 00:00 [pmc-release]
AID - 10.1038/s41598-023-43459-2 [pii]
AID - 43459 [pii]
AID - 10.1038/s41598-023-43459-2 [doi]
PST - epublish
SO  - Sci Rep. 2023 Sep 27;13(1):16259. doi: 10.1038/s41598-023-43459-2.