PMID- 37759473
OWN - NLM
STAT- MEDLINE
DCOM- 20230929
LR  - 20231003
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 12
IP  - 18
DP  - 2023 Sep 11
TI  - Metabolomics Profile of the Secretome of Space-Flown Oligodendrocytes.
LID - 10.3390/cells12182249 [doi]
LID - 2249
AB  - Intracranial hypertension (ICP) and visual impairment intracranial pressure 
      (VIIP) are some of the sequels of long-term space missions. Here we sought to 
      determine how space microgravity (microG) impacts the metabolomics profile of 
      oligodendrocyte progenitors (OLPs), the myelin-forming cells in the central 
      nervous system. We report increased glutamate and energy metabolism while the 
      OLPs were in space for 26 days. We also show that after space flight, OLPs (SPC 
      OLPs) display significantly increased mitochondrial respiration and glycolysis. 
      These data are in agreement with our previous work using simulated microgravity. 
      In addition, our global metabolomics approach allowed for the discovery of 
      endogenous metabolites secreted by OLPs while in space that are significantly 
      modulated by microgravity. Our results provide, for the first time, relevant 
      information about the energetic state of OLPs while in space and after space 
      flight. The functional and molecular relevance of these specific pathways are 
      promising targets for therapeutic intervention for humans in long-term space 
      missions to the moon, Mars and beyond.
FAU - Vergnes, Laurent
AU  - Vergnes L
AUID- ORCID: 0000-0002-8804-589X
AD  - Department of Human Genetics, David Geffen School of Medicine, University of 
      California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Foucaud, Bernard
AU  - Foucaud B
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Cepeda, Carlos
AU  - Cepeda C
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Espinosa-Jeffrey, Araceli
AU  - Espinosa-Jeffrey A
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      University of California Los Angeles, Los Angeles, CA 90095, USA.
LA  - eng
GR  - F32 HD008710/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230911
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Humans
MH  - *Secretome
MH  - *Metabolomics
MH  - Oligodendroglia
MH  - Myelin Sheath
MH  - Glutamic Acid
PMC - PMC10528075
OTO - NOTNLM
OT  - global metabolomics
OT  - microgravity
OT  - oligodendrocyte progenitor energetics
OT  - oligodendrocyte progenitors
COIS- The authors report no conflict of interest.
EDAT- 2023/09/28 06:43
MHDA- 2023/09/29 06:43
PMCR- 2023/09/11
CRDT- 2023/09/28 01:01
PHST- 2023/08/21 00:00 [received]
PHST- 2023/09/06 00:00 [revised]
PHST- 2023/09/06 00:00 [accepted]
PHST- 2023/09/29 06:43 [medline]
PHST- 2023/09/28 06:43 [pubmed]
PHST- 2023/09/28 01:01 [entrez]
PHST- 2023/09/11 00:00 [pmc-release]
AID - cells12182249 [pii]
AID - cells-12-02249 [pii]
AID - 10.3390/cells12182249 [doi]
PST - epublish
SO  - Cells. 2023 Sep 11;12(18):2249. doi: 10.3390/cells12182249.