PMID- 37759895
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 13
IP  - 9
DP  - 2023 Sep 7
TI  - Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel 
      Synthetic Cathinone Eutylone.
LID - 10.3390/brainsci13091294 [doi]
LID - 1294
AB  - BACKGROUND: As individual synthetic cathinones become scheduled and regulated by 
      the Drug Enforcement Administration (DEA), new ones regularly are produced and 
      distributed. One such compound is eutylone, a novel third-generation synthetic 
      cathinone whose affective properties (and abuse potential) are largely unknown. 
      The following experiments begin to characterize these effects and how they may be 
      impacted by drug history (a factor affecting reward/aversion for other drugs of 
      abuse). METHODS: Eutylone was assessed for its ability to induce conditioned 
      taste avoidance (CTA; aversive effect) and conditioned place preference (CPP; 
      rewarding effect) and their relationship (Experiment 1). Following this, the 
      effects of exposure to cocaine or 3,4-methylenedioxymethamphetamine [MDMA] on 
      eutylone's affective properties were investigated (Experiment 2). RESULTS: 
      Eutylone produced dose-dependent CTA and CPP (Experiment 1), and these endpoints 
      were unrelated. Pre-exposure to cocaine and MDMA differentially impacted taste 
      avoidance induced by eutylone (MDMA > cocaine) and did not impact 
      eutylone-induced place preference. CONCLUSIONS: These data indicate that 
      eutylone, like other synthetic cathinones, has co-occurring, independent 
      rewarding and aversive effects that may contribute to its abuse potential and 
      that these effects are differentially impacted by drug history. Although these 
      studies begin the characterization of eutylone, future studies should examine the 
      impact of other factors on eutylone's affective properties and its eventual 
      reinforcing effects (i.e., intravenous self-administration [IVSA]) to predict its 
      use and abuse liability.
FAU - Manke, Hayley N
AU  - Manke HN
AUID- ORCID: 0000-0002-8889-957X
AD  - Psychopharmacology Laboratory, Center for Neuroscience and Behavior, Department 
      of Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, DC 
      20016, USA.
FAU - Nunn, Samuel S
AU  - Nunn SS
AUID- ORCID: 0009-0009-1978-2480
AD  - Psychopharmacology Laboratory, Center for Neuroscience and Behavior, Department 
      of Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, DC 
      20016, USA.
FAU - Sulima, Agnieszka
AU  - Sulima A
AD  - Drug Design and Synthesis Section, National Institute on Drug Abuse (NIDA), 
      National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD 20892, 
      USA.
FAU - Rice, Kenner C
AU  - Rice KC
AUID- ORCID: 0000-0002-1147-9147
AD  - Drug Design and Synthesis Section, National Institute on Drug Abuse (NIDA), 
      National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD 20892, 
      USA.
FAU - Riley, Anthony L
AU  - Riley AL
AD  - Psychopharmacology Laboratory, Center for Neuroscience and Behavior, Department 
      of Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, DC 
      20016, USA.
LA  - eng
GR  - N/A/Andrew Mellon Foundation/
GR  - N/A/American University College of Arts and Sciences/
PT  - Journal Article
DEP - 20230907
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC10526358
OTO - NOTNLM
OT  - MDMA
OT  - cocaine
OT  - drug history
OT  - eutylone
OT  - place preference
OT  - taste avoidance
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:43
PMCR- 2023/09/07
CRDT- 2023/09/28 01:03
PHST- 2023/08/02 00:00 [received]
PHST- 2023/08/31 00:00 [revised]
PHST- 2023/09/02 00:00 [accepted]
PHST- 2023/09/28 06:43 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:03 [entrez]
PHST- 2023/09/07 00:00 [pmc-release]
AID - brainsci13091294 [pii]
AID - brainsci-13-01294 [pii]
AID - 10.3390/brainsci13091294 [doi]
PST - epublish
SO  - Brain Sci. 2023 Sep 7;13(9):1294. doi: 10.3390/brainsci13091294.