PMID- 37760638
OWN - NLM
STAT- Publisher
LR  - 20231003
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 18
DP  - 2023 Sep 21
TI  - Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients 
      Treated with Chemotherapy.
LID - 10.3390/cancers15184670 [doi]
LID - 4670
AB  - BACKGROUND: Determining the risk of grade 3-5 toxicity and early death (ED) is 
      important to plan chemotherapy in older adult patients with cancer. Our objective 
      was to identify factors predicting these complications at the time of treatment 
      initiation. METHODS: 234 patients aged >/=70 were subjected to a geriatric 
      assessment and variables related to the tumor and the treatment were also 
      collected. Logistic regression multivariable analysis was used to relate these 
      factors with the appearance of grade 3-5 toxicity and ED. Predictive scores for 
      both toxicity and ED were then developed. RESULTS: Factors related to grade 3-5 
      toxicity were hemoglobin, MAX2 index, ADL, and the CONUT score. Factors related 
      to ED were tumor stage and the GNRI score. Two predictive scores were developed 
      using these variables. ROC curves for the prediction of toxicity and ED were 0.71 
      (95% CI: 0.64-0.78) and 0.73 (95% CI: 0.68-0.79), respectively. CONCLUSIONS: Two 
      simple and reliable scores were developed to predict grade 3-5 toxicity and ED in 
      older adult patients with cancer. This may be helpful in treatment planning.
FAU - Feliu, Jaime
AU  - Feliu J
AUID- ORCID: 0000-0003-4867-1420
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
AD  - Catedra UAM-AMGEN de Oncologia Medica y Medicina Paliativa, Facultad de Medicina, 
      Universidad Autonoma de Madrid, 28029 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red del Cancer (CIBERONC), Instituto de 
      Salud Carlos III, 28029 Madrid, Spain.
FAU - Custodio, Ana Belen
AU  - Custodio AB
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red del Cancer (CIBERONC), Instituto de 
      Salud Carlos III, 28029 Madrid, Spain.
FAU - Pinto-Marin, Alvaro
AU  - Pinto-Marin A
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Higuera, Oliver
AU  - Higuera O
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Perez-Gonzalez, Miriam
AU  - Perez-Gonzalez M
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Del Pino, Laura
AU  - Del Pino L
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Ruiz-Jimenez, Leticia
AU  - Ruiz-Jimenez L
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Sanchez-Cabero, Dario
AU  - Sanchez-Cabero D
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Viera, Isabel
AU  - Viera I
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Jurado, Ana
AU  - Jurado A
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
FAU - Espinosa, Enrique
AU  - Espinosa E
AUID- ORCID: 0000-0001-6562-7902
AD  - Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, 
      Hospital Universitario La Paz, 28029 Madrid, Spain.
AD  - Catedra UAM-AMGEN de Oncologia Medica y Medicina Paliativa, Facultad de Medicina, 
      Universidad Autonoma de Madrid, 28029 Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red del Cancer (CIBERONC), Instituto de 
      Salud Carlos III, 28029 Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20230921
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10526243
OTO - NOTNLM
OT  - cancer
OT  - chemotherapy
OT  - early death
OT  - older adult patient
OT  - prognostic
OT  - toxicity
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:42
PMCR- 2023/09/21
CRDT- 2023/09/28 01:08
PHST- 2023/07/18 00:00 [received]
PHST- 2023/09/12 00:00 [revised]
PHST- 2023/09/18 00:00 [accepted]
PHST- 2023/09/28 06:42 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:08 [entrez]
PHST- 2023/09/21 00:00 [pmc-release]
AID - cancers15184670 [pii]
AID - cancers-15-04670 [pii]
AID - 10.3390/cancers15184670 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Sep 21;15(18):4670. doi: 10.3390/cancers15184670.