PMID- 37760964
OWN - NLM
STAT- Publisher
LR  - 20231003
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 9
DP  - 2023 Sep 13
TI  - Minimal Clinically Important Differences in EQ-5D-5L Index and VAS after a 
      Respiratory Muscle Training Program in Individuals Experiencing Long-Term 
      Post-COVID-19 Symptoms.
LID - 10.3390/biomedicines11092522 [doi]
LID - 2522
AB  - The primary aim of this study was to determine the minimal clinically important 
      difference (MCID) for the EuroQol-5D questionnaire (EQ-5D-5L) index and visual 
      analogic scale (VAS) in individuals experiencing long-term post-COVID-19 
      symptoms. In addition, it was pretended to determine which variable discriminates 
      better and to compare changes between individuals classified by the MCID. DESIGN: 
      Secondary analysis of a randomized controlled trial involving 42 individuals who 
      underwent an 8-week intervention in a respiratory muscle training program. 
      RESULTS: A change of at least 0.262 and 7.5 for the EQ-5D-5L index and VAS 
      represented the MCID, respectively. Only the EQ-5D-5L VAS showed acceptable 
      discrimination between individuals who were classified as "improved" and those 
      classified as "stable/not improved" (area under the curve = 0.78), although with 
      a low Youden index (Youden index, 0.39; sensitivity, 46.2%; specificity, 93.1%). 
      Those individuals who exceeded the established MCID for EQ-5D-5L VAS had 
      significantly greater improvements in inspiratory muscle function, exercise 
      tolerance, and peripheral muscle strength compared to participants classified as 
      "stable/not improved". CONCLUSIONS: Only the EQ-5D-5L VAS, especially when MCID 
      was exceeded, showed an acceptable discriminative ability to evaluate the 
      efficacy of an intervention in individuals with long-term post-COVID-19 symptoms.
FAU - Del Corral, Tamara
AU  - Del Corral T
AUID- ORCID: 0000-0002-3144-5411
AD  - Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, 
      Physiotherapy and Podiatry, Universidad Complutense de Madrid (UCM), 28040 
      Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28040 Madrid, Spain.
FAU - Fabero-Garrido, Raul
AU  - Fabero-Garrido R
AUID- ORCID: 0000-0002-6565-4967
AD  - Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, 
      Physiotherapy and Podiatry, Universidad Complutense de Madrid (UCM), 28040 
      Madrid, Spain.
FAU - Plaza-Manzano, Gustavo
AU  - Plaza-Manzano G
AUID- ORCID: 0000-0003-1596-5027
AD  - Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, 
      Physiotherapy and Podiatry, Universidad Complutense de Madrid (UCM), 28040 
      Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28040 Madrid, Spain.
FAU - Navarro-Santana, Marcos Jose
AU  - Navarro-Santana MJ
AUID- ORCID: 0000-0002-6065-9283
AD  - Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, 
      Physiotherapy and Podiatry, Universidad Complutense de Madrid (UCM), 28040 
      Madrid, Spain.
FAU - Fernandez-de-Las-Penas, Cesar
AU  - Fernandez-de-Las-Penas C
AUID- ORCID: 0000-0003-3772-9690
AD  - Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical 
      Medicine, Universidad Rey Juan Carlos, 28922 Alcorcon, Spain.
FAU - Lopez-de-Uralde-Villanueva, Ibai
AU  - Lopez-de-Uralde-Villanueva I
AUID- ORCID: 0000-0001-7474-5257
AD  - Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing, 
      Physiotherapy and Podiatry, Universidad Complutense de Madrid (UCM), 28040 
      Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28040 Madrid, Spain.
LA  - eng
GR  - IP.A.I. Covid-19 2020/03/Colegio Profesional de Fisioterapeutas de Madrid/
PT  - Journal Article
DEP - 20230913
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10526144
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - euroqol-5D-5L
OT  - health-related quality of life
OT  - minimal clinically important difference
OT  - responsiveness
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:42
PMCR- 2023/09/13
CRDT- 2023/09/28 01:09
PHST- 2023/07/23 00:00 [received]
PHST- 2023/08/21 00:00 [revised]
PHST- 2023/09/11 00:00 [accepted]
PHST- 2023/09/28 06:42 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:09 [entrez]
PHST- 2023/09/13 00:00 [pmc-release]
AID - biomedicines11092522 [pii]
AID - biomedicines-11-02522 [pii]
AID - 10.3390/biomedicines11092522 [doi]
PST - epublish
SO  - Biomedicines. 2023 Sep 13;11(9):2522. doi: 10.3390/biomedicines11092522.