PMID- 37761249
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230930
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 18
DP  - 2023 Sep 8
TI  - How Does Anxiety and Depression Affect the Outcome after Periradicular 
      Infiltration Therapy?-A Retrospective Analysis of Patients Undergoing CT-Guided 
      Single-Level Nerve Root Infiltration Due to Chronic Monoradicular Pain.
LID - 10.3390/diagnostics13182882 [doi]
LID - 2882
AB  - The aim of this study was to research the influence of psychological confounders 
      on patient-reported outcomes (PROs) after lumbar infiltration therapies of 
      periradicular infiltrations (PRI). Patients who underwent PRI in a single center 
      between June 2018 and December 2019 were included. PRI was performed in patients 
      with predominantly unilateral lumbar radiculopathy which existed for at least 6 
      weeks based on single-level nerve root compression (caused by a herniated disc, 
      stenosis of the lateral recess, or neuroforamen), confirmed by morphological 
      imaging. The numeric pain rating scale (NRS) for back pain (BP) and leg pain (LP) 
      and the Oswestry Disability Index (ODI) were assessed preinterventionally, on the 
      first day (only NRS) and at 6 weeks, and then 3, 6, and 12 months 
      postinterventionally. The minimally clinically important difference (MCID) served 
      as the threshold for the therapeutic effectiveness evaluation. The health-related 
      quality of life (SF-36) was recorded preinterventionally and after 12 months. 
      Based on the Hospital Anxiety and Depression Scale, the patients were 
      dichotomized into depressed or nondepressed and anxious or nonanxious. 
      Categorical data were evaluated using Fisher's exact test, and continuous data 
      were evaluated using Student's t test. Separate linear mixed models were built to 
      estimate the effect of anxiety or depression on repeatedly measured PROs 
      following PRI. Data were analyzed using SPSS software. The analysis included 102 
      patients. Most mean baseline PROs were significantly worse in anxious or 
      depressed patients than in nonanxious or nondepressed patients: Anxiety NRS-BP (p 
      = 0.007), ODI (p < 0.001); Depression NRS-BP (p = 0.026), NRS-LP (p < 0.001), ODI 
      (p < 0.001). All patients showed a clinically meaningful reduction in pain and 
      functional improvement over a 12-month follow-up. There was no significant 
      difference in the estimated overall mean PRO between all patients (p > 0.05). In 
      conclusion, anxiety and depression are associated with worse PROs before and 
      after PRI. However, patients with underlying depression or anxiety can expect a 
      similar gain in PRO compared to patients without depressive or anxious symptoms.
FAU - Lindemann, Chris
AU  - Lindemann C
AD  - Orthopedic Department, Jena University Hospital, Campus Eisenberg, Friedrich 
      Schiller University, 07607 Eisenberg, Germany.
FAU - Holzl, Alexander
AU  - Holzl A
AD  - Orthopedic Department, Jena University Hospital, Campus Eisenberg, Friedrich 
      Schiller University, 07607 Eisenberg, Germany.
FAU - Bohle, Sabrina
AU  - Bohle S
AUID- ORCID: 0000-0002-6976-8953
AD  - Orthopedic Department, Jena University Hospital, Campus Eisenberg, Friedrich 
      Schiller University, 07607 Eisenberg, Germany.
FAU - Zippelius, Timo
AU  - Zippelius T
AD  - Department of Orthopedic Surgery, University of Ulm, 89081 Ulm, Germany.
FAU - Strube, Patrick
AU  - Strube P
AD  - Orthopedic Department, Jena University Hospital, Campus Eisenberg, Friedrich 
      Schiller University, 07607 Eisenberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230908
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10527802
OTO - NOTNLM
OT  - anxiety
OT  - chronic low back pain
OT  - depression
OT  - lumbar spine
OT  - periradicular infiltration
OT  - radiculopathy
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:43
MHDA- 2023/09/28 06:44
PMCR- 2023/09/08
CRDT- 2023/09/28 01:11
PHST- 2023/07/17 00:00 [received]
PHST- 2023/08/23 00:00 [revised]
PHST- 2023/09/05 00:00 [accepted]
PHST- 2023/09/28 06:44 [medline]
PHST- 2023/09/28 06:43 [pubmed]
PHST- 2023/09/28 01:11 [entrez]
PHST- 2023/09/08 00:00 [pmc-release]
AID - diagnostics13182882 [pii]
AID - diagnostics-13-02882 [pii]
AID - 10.3390/diagnostics13182882 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Sep 8;13(18):2882. doi: 10.3390/diagnostics13182882.