PMID- 37761488
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 10
IP  - 9
DP  - 2023 Sep 8
TI  - Similarities and Differences between Multisystem Inflammatory Syndrome in 
      Children (MIS-C) and Kawasaki Disease Shock Syndrome.
LID - 10.3390/children10091527 [doi]
LID - 1527
AB  - This study aimed to investigate the characteristics of COVID-19-associated 
      multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock 
      syndrome (KDSS) and to compare the similarities and differences between the two 
      diseases. The incidence of KDSS and MIS-C was also estimated. Medical records of 
      patients diagnosed with MIS-C or KDSS at four hospitals from January 2013 to 
      December 2022 were retrospectively reviewed. Thirty-one patients were enrolled in 
      the study in either an MIS-C group (n = 22) or a KDSS group (n = 9). The 
      incidence of KDSS in KD was 0.8% (9/1095) and the incidence of MIS-C versus KD 
      was 10.2% (22/216). Compared with the MIS-C group, the KDSS group had longer 
      hospital stays and more severe systemic inflammation (e.g., anemia, elevated 
      C-reactive protein, hypoalbuminemia, and pyuria) and organ dysfunction (e.g., 
      number of involved organs, shock, vasoactive infusion, and intensive care unit 
      admission). All patients in the MIS-C group, but none in the KDSS group, 
      including two patients during the COVID-19 pandemic, had laboratory evidence of 
      SARS-CoV-2 infection. MIS-C and KDSS shared demographic, clinical, and laboratory 
      characteristics; organ dysfunction; treatment; and outcomes. Overall severity was 
      more severe in patients with KDSS than in those with MIS-C. The most important 
      difference between MIS-C and KDSS was whether SARS-CoV-2 was identified as an 
      infectious trigger.
FAU - Lee, Jin
AU  - Lee J
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul 06591, Republic of Korea.
AD  - Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of 
      Korea, Incheon 21431, Republic of Korea.
FAU - Kim, Beom Joon
AU  - Kim BJ
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul 06591, Republic of Korea.
AD  - Department of Pediatrics, Eunpyeong St. Mary's Hospital, The Catholic University 
      of Korea, Seoul 03312, Republic of Korea.
FAU - Cho, Kyoung-Soon
AU  - Cho KS
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul 06591, Republic of Korea.
AD  - Department of Pediatrics, Bucheon St. Mary's Hospital, The Catholic University of 
      Korea, Bucheon 14647, Republic of Korea.
FAU - Rhim, Jung Woo
AU  - Rhim JW
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul 06591, Republic of Korea.
AD  - Department of Pediatrics, Daejeon St. Mary's Hospital, The Catholic University of 
      Korea, Daejeon 34943, Republic of Korea.
FAU - Lee, Soo-Young
AU  - Lee SY
AUID- ORCID: 0000-0002-5354-3135
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul 06591, Republic of Korea.
AD  - Department of Pediatrics, Bucheon St. Mary's Hospital, The Catholic University of 
      Korea, Bucheon 14647, Republic of Korea.
AD  - The Vaccine Bio Research Institute, College of Medicine, The Catholic University 
      of Korea, Seoul 06591, Republic of Korea.
FAU - Jeong, Dae Chul
AU  - Jeong DC
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul 06591, Republic of Korea.
AD  - The Vaccine Bio Research Institute, College of Medicine, The Catholic University 
      of Korea, Seoul 06591, Republic of Korea.
AD  - Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of 
      Korea, Seoul 06591, Republic of Korea.
LA  - eng
GR  - Research Fund, 2023/Bucheon St. Mary's Hospital/
PT  - Journal Article
DEP - 20230908
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10527784
OTO - NOTNLM
OT  - Kawasaki disease
OT  - Kawasaki disease shock syndrome
OT  - multisystem inflammatory syndrome in children
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:43
PMCR- 2023/09/08
CRDT- 2023/09/28 01:13
PHST- 2023/08/17 00:00 [received]
PHST- 2023/09/06 00:00 [revised]
PHST- 2023/09/07 00:00 [accepted]
PHST- 2023/09/28 06:43 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:13 [entrez]
PHST- 2023/09/08 00:00 [pmc-release]
AID - children10091527 [pii]
AID - children-10-01527 [pii]
AID - 10.3390/children10091527 [doi]
PST - epublish
SO  - Children (Basel). 2023 Sep 8;10(9):1527. doi: 10.3390/children10091527.