PMID- 37762140
OWN - NLM
STAT- MEDLINE
DCOM- 20230930
LR  - 20231003
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 18
DP  - 2023 Sep 8
TI  - Acute Glycemic Control in Prediabetes Individuals Favorably Alters Serum NLRP3 
      Inflammasome and Related Interleukins.
LID - 10.3390/ijms241813837 [doi]
LID - 13837
AB  - Hyperglycemia associated with prediabetes (PD) alters NLRP3 inflammasome activity 
      and related interleukins, yet no study has evaluated the expression of the NLRP3 
      inflammasome complex and related interleukins in individuals with a PD condition 
      that did or did not develop type 2 diabetes mellitus (T2DM). This study 
      investigated the effect of 6 months of lifestyle modification on the expression 
      of the NLRP3 inflammasome and related interleukins (1alpha, 1beta, 18, 33 and 37) in the 
      sera of individuals with a PD condition that did or did not develop T2DM. This 
      interventional study included 67 Saudi adults (mean age = 41.9 +/- 8.0 years, mean 
      BMI = 33.2 +/- 5.5 kg/m(2)). Overnight-fasting serum samples were collected at 
      baseline and at the 6-month follow-up. Serum levels of NLRP3, capsase-1 and 
      related ILs were analyzed at both visits using commercially available immunoassay 
      kits. Results showed that IL-1alpha increased in the PD group that developed T2DM (p 
      = 0.046), IL-33 decreased in the PD group that reverted to normal (p < 0.001) and 
      NLRP3 decreased in the PD group that remained PD (p = 0.01). Results also showed 
      a positive over-time correlation between NLRP3 and both IL-1alpha and IL-33 (p < 
      0.001 and p = 0.028, respectively). In conclusion, glycemic control favorably 
      altered NLRP3 inflammasome complex activity, and lifestyle modification in PD 
      individuals is crucial in reversing harmful metabolic and inflammatory 
      phenotypes.
FAU - Alfadul, Hend
AU  - Alfadul H
AUID- ORCID: 0009-0007-8086-937X
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
FAU - Sabico, Shaun
AU  - Sabico S
AUID- ORCID: 0000-0002-5248-2350
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
FAU - Alnaami, Abdullah M
AU  - Alnaami AM
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
FAU - Amer, Osama E
AU  - Amer OE
AUID- ORCID: 0000-0002-8657-0682
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
FAU - Hussain, Syed D
AU  - Hussain SD
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
FAU - Wani, Kaiser
AU  - Wani K
AUID- ORCID: 0000-0001-9568-6516
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
FAU - Clerici, Mario
AU  - Clerici M
AUID- ORCID: 0000-0001-5920-6191
AD  - Department of Medical-Surgery Physiopathology and Transplantation, University of 
      Milan, 20122 Milan, Italy.
FAU - Al-Daghri, Nasser M
AU  - Al-Daghri NM
AUID- ORCID: 0000-0001-5472-1725
AD  - Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of 
      Science, King Saud University, Riyadh 11451, Saudi Arabia.
LA  - eng
GR  - IFKSUDR_H174/Deputyship for Research and Innovation, Ministry of Education in 
      Saudi Arabia/
PT  - Journal Article
DEP - 20230908
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-33)
RN  - 0 (Interleukins)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - *Diabetes Mellitus, Type 2
MH  - Glycemic Control
MH  - Inflammasomes
MH  - Interleukin-33
MH  - Interleukins
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - *Prediabetic State
PMC - PMC10530894
OTO - NOTNLM
OT  - NLRP3
OT  - chronic inflammation
OT  - inflammasomes
OT  - inflammatory disease
OT  - interleukins
OT  - prediabetes
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:43
MHDA- 2023/09/29 06:44
PMCR- 2023/09/08
CRDT- 2023/09/28 01:17
PHST- 2023/08/08 00:00 [received]
PHST- 2023/09/03 00:00 [revised]
PHST- 2023/09/07 00:00 [accepted]
PHST- 2023/09/29 06:44 [medline]
PHST- 2023/09/28 06:43 [pubmed]
PHST- 2023/09/28 01:17 [entrez]
PHST- 2023/09/08 00:00 [pmc-release]
AID - ijms241813837 [pii]
AID - ijms-24-13837 [pii]
AID - 10.3390/ijms241813837 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Sep 8;24(18):13837. doi: 10.3390/ijms241813837.