PMID- 37762992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 18
DP  - 2023 Sep 19
TI  - Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on 
      Diabetic Microvascular Complications.
LID - 10.3390/jcm12186053 [doi]
LID - 6053
AB  - Type 2 diabetes mellitus (T2DM) still holds the title as one of the most 
      debilitating chronic diseases with rising prevalence and incidence, including its 
      complications such as retinal, renal, and peripheral nerve disease. In order to 
      develop novel molecules for diagnosis and treatment, a deep understanding of the 
      complex molecular pathways is imperative. Currently, the existing agents for T2DM 
      treatment target only blood glucose levels. Over the past decades, specific 
      building blocks of proteins-branched-chain amino acids (BCAAs) including leucine, 
      isoleucine, and valine-have gained attention because they are linked with insulin 
      resistance, pre-diabetes, and diabetes development. In this review, we discuss 
      the hypothetical link between BCAA metabolism, insulin resistance, T2DM, and its 
      microvascular complications including diabetic retinopathy and diabetic 
      nephropathy. Further research on these amino acids and their derivates may 
      eventually pave the way to novel biomarkers or therapeutic concepts for the 
      treatment of diabetes and its accompanied complications.
FAU - Tanase, Daniela Maria
AU  - Tanase DM
AUID- ORCID: 0000-0002-7144-2506
AD  - Department of Internal Medicine, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital Iasi, 
      700111 Iasi, Romania.
FAU - Gosav, Evelina Maria
AU  - Gosav EM
AUID- ORCID: 0000-0003-1730-9306
AD  - Department of Internal Medicine, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital Iasi, 
      700111 Iasi, Romania.
FAU - Botoc, Tina
AU  - Botoc T
AD  - Department of Ophthalmology, Faculty of Medicine, "Grigore T. Popa" University of 
      Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - 2nd Ophthalmology Clinic, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, 
      700309 Iasi, Romania.
FAU - Floria, Mariana
AU  - Floria M
AUID- ORCID: 0000-0002-9465-1503
AD  - Department of Internal Medicine, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital Iasi, 
      700111 Iasi, Romania.
FAU - Tarniceriu, Claudia Cristina
AU  - Tarniceriu CC
AD  - Department of Morpho-Functional Sciences I, Discipline of Anatomy, "Grigore T. 
      Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - Hematology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 
      Iasi, Romania.
FAU - Maranduca, Minela Aida
AU  - Maranduca MA
AUID- ORCID: 0000-0002-2736-9700
AD  - Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital Iasi, 
      700111 Iasi, Romania.
AD  - Department of Morpho-Functional Sciences II, Discipline of Physiology, "Grigore 
      T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
FAU - Haisan, Anca
AU  - Haisan A
AUID- ORCID: 0000-0001-8073-8192
AD  - Department of Emergency Medicine, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Emergency Department, "St. Spiridon" County Clinical Emergency Hospital, 700111 
      Iasi, Romania.
FAU - Cucu, Andrei Ionut
AU  - Cucu AI
AUID- ORCID: 0000-0003-1441-1751
AD  - Department of Biomedical Sciences, Faculty of Medicine and Biological Sciences, 
      "Stefan cel Mare" University, 720229 Suceava, Romania.
AD  - Department of Neurosurgery, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, 
      700309 Iasi, Romania.
FAU - Rezus, Ciprian
AU  - Rezus C
AUID- ORCID: 0000-0003-1155-7325
AD  - Department of Internal Medicine, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
AD  - Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital Iasi, 
      700111 Iasi, Romania.
FAU - Costea, Claudia Florida
AU  - Costea CF
AD  - Department of Ophthalmology, Faculty of Medicine, "Grigore T. Popa" University of 
      Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - 2nd Ophthalmology Clinic, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, 
      700309 Iasi, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230919
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10531730
OTO - NOTNLM
OT  - BCAAs
OT  - T2DM
OT  - branched chain amino acids
OT  - diabetes mellitus
OT  - diabetic nephropathy
OT  - diabetic retinopathy
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:43
PMCR- 2023/09/19
CRDT- 2023/09/28 01:23
PHST- 2023/08/21 00:00 [received]
PHST- 2023/09/10 00:00 [revised]
PHST- 2023/09/17 00:00 [accepted]
PHST- 2023/09/28 06:43 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:23 [entrez]
PHST- 2023/09/19 00:00 [pmc-release]
AID - jcm12186053 [pii]
AID - jcm-12-06053 [pii]
AID - 10.3390/jcm12186053 [doi]
PST - epublish
SO  - J Clin Med. 2023 Sep 19;12(18):6053. doi: 10.3390/jcm12186053.