PMID- 37763905 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231003 IS - 2072-666X (Print) IS - 2072-666X (Electronic) IS - 2072-666X (Linking) VI - 14 IP - 9 DP - 2023 Sep 6 TI - Femtosecond Laser Direct Writing of Gecko-Inspired Switchable Adhesion Interfaces on a Flexible Substrate. LID - 10.3390/mi14091742 [doi] LID - 1742 AB - Biomimetic switchable adhesion interfaces (BSAIs) with dynamic adhesion states have demonstrated significant advantages in micro-manipulation and bio-detection. Among them, gecko-inspired adhesives have garnered considerable attention due to their exceptional adaptability to extreme environments. However, their high adhesion strength poses challenges in achieving flexible control. Herein, we propose an elegant and efficient approach by fabricating three-dimensional mushroom-shaped polydimethylsiloxane (PDMS) micropillars on a flexible PDMS substrate to mimic the bending and stretching of gecko footpads. The fabrication process that employs two-photon polymerization ensures high spatial resolution, resulting in micropillars with exquisite structures and ultra-smooth surfaces, even for tip/stem ratios exceeding 2 (a critical factor for maintaining adhesion strength). Furthermore, these adhesive structures display outstanding resilience, enduring 175% deformation and severe bending without collapse, ascribing to the excellent compatibility of the micropillar's composition and physical properties with the substrate. Our BSAIs can achieve highly controllable adhesion force and rapid manipulation of liquid droplets through mechanical bending and stretching of the PDMS substrate. By adjusting the spacing between the micropillars, precise control of adhesion strength is achieved. These intriguing properties make them promising candidates for various applications in the fields of microfluidics, micro-assembly, flexible electronics, and beyond. FAU - Zhang, Zhiang AU - Zhang Z AD - Department of Automation, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - He, Bingze AU - He B AD - Institute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Han, Qingqing AU - Han Q AD - Department of Automation, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - He, Ruokun AU - He R AD - Department of Automation, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Ding, Yuxuan AU - Ding Y AD - Institute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Han, Bing AU - Han B AUID- ORCID: 0000-0001-9763-0372 AD - Institute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Ma, Zhuo-Chen AU - Ma ZC AUID- ORCID: 0000-0002-0207-6039 AD - Department of Automation, Shanghai Jiao Tong University, Shanghai 200240, China. AD - Institute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. LA - eng GR - Nos. 62205200 and 62005141/National Natural Science Foundation of China/ GR - 22ZR1431600/Natural Science Foundation of Shanghai/ GR - 2021SHZDZX/Shanghai Municipal Science and Technology Major Project/ PT - Journal Article DEP - 20230906 PL - Switzerland TA - Micromachines (Basel) JT - Micromachines JID - 101640903 PMC - PMC10534918 OTO - NOTNLM OT - mushroom-shaped micropillars OT - switchable adhesion OT - two-photon polymerization COIS- The authors declare no conflict of interest. EDAT- 2023/09/28 06:43 MHDA- 2023/09/28 06:44 PMCR- 2023/09/06 CRDT- 2023/09/28 01:29 PHST- 2023/08/09 00:00 [received] PHST- 2023/08/31 00:00 [revised] PHST- 2023/09/04 00:00 [accepted] PHST- 2023/09/28 06:44 [medline] PHST- 2023/09/28 06:43 [pubmed] PHST- 2023/09/28 01:29 [entrez] PHST- 2023/09/06 00:00 [pmc-release] AID - mi14091742 [pii] AID - micromachines-14-01742 [pii] AID - 10.3390/mi14091742 [doi] PST - epublish SO - Micromachines (Basel). 2023 Sep 6;14(9):1742. doi: 10.3390/mi14091742.