PMID- 37764518
OWN - NLM
STAT- MEDLINE
DCOM- 20230929
LR  - 20231003
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 28
IP  - 18
DP  - 2023 Sep 21
TI  - Potential of Natural Phenolic Compounds as Antimicrobial Agents against 
      Multidrug-Resistant Staphylococcus aureus in Chicken Meat.
LID - 10.3390/molecules28186742 [doi]
LID - 6742
AB  - Staphylococcus aureus is one of the most widespread foodborne bacteria that cause 
      high morbidity, mortality, and economic loss, primarily if foodborne diseases are 
      caused by pathogenic and multidrug-resistant (MDR) strains. This study aimed to 
      determine the prevalence of S. aureus in chicken meat in Egyptian markets. Thus, 
      this study might be the first to assess the efficiency of different natural 
      phenolic compounds as novel antibacterial agents against MDR S. aureus pathogens 
      isolated from raw chicken meat in the Egyptian market. The incidence and 
      quantification of pathogenic S. aureus were detected in retail raw chicken meat 
      parts (breast, thigh, fillet, and giblets). In total, 73 out of 80 (91.3%) of the 
      chicken meat parts were contaminated, with S. aureus as the only species 
      isolated. Of the 192 identified S. aureus isolates, 143 were coagulase-positive 
      S. aureus and 117 isolates were MDR (81.8%, 117/143). Twenty-two antibiotic 
      resistance profile patterns were detected. One strain was randomly selected from 
      each pattern to further analyze virulence and resistance genes. Extracted DNA was 
      assessed for the presence of antibiotic-resistance genes, i.e., 
      vancomycin-resistance (vanA), aminoglycosides-resistance (aacA-aphD), 
      apramycin-resistance (apmA), and methicillin-resistance (mecA), 
      penicillin-resistance (blaZ), and virulence genes staphylococcal enterotoxins 
      (sea and seb), Panton-Valentine leucocidin (pvl), clumping factor A (clfA), and 
      toxic shock syndrome toxin (tst). Clustering analyses revealed that six S. aureus 
      strains harbored the most virulence and resistance genes. The activity of 
      hydroquinone was significantly higher than thymol, carvacrol, eugenol, and 
      protocatechuic acid. Therefore, phenolic compounds, particularly hydroquinone, 
      could potentially alternate with conventional antibiotics against the pathogenic 
      MDR S. aureus inhabiting raw chicken meat. Hence, this study indicates that 
      urgent interventions are necessary to improve hygiene for safer meat in Egyptian 
      markets. Moreover, hydroquinone could be a natural phenolic compound for 
      inhibiting foodborne pathogens.
FAU - Morshdy, Alaa Eldin M A
AU  - Morshdy AEMA
AD  - Food Hygiene, Safety, and Technology Department, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig 44519, Egypt.
FAU - Abdallah, Karima M E
AU  - Abdallah KME
AD  - Food Hygiene, Safety, and Technology Department, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig 44519, Egypt.
FAU - Abdallah, Heba E
AU  - Abdallah HE
AD  - Food Hygiene, Safety, and Technology Department, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig 44519, Egypt.
FAU - Algahtani, Fahad D
AU  - Algahtani FD
AUID- ORCID: 0000-0003-1247-9154
AD  - Department of Public Health, College of Public Health and Health Informatics, 
      University of Hail, Ha'il 81451, Saudi Arabia.
FAU - Elabbasy, Mohamed Tharwat
AU  - Elabbasy MT
AUID- ORCID: 0000-0002-0138-825X
AD  - College of Medicine, University of Ha'il, Ha'il 55473, Saudi Arabia.
FAU - Atique, Suleman
AU  - Atique S
AUID- ORCID: 0000-0002-5149-0703
AD  - Department of Public Health Science, Faculty of Landscape and Society, Norwegian 
      University of Life Sciences, 1430 As, Norway.
FAU - Ahmad, Khursheed
AU  - Ahmad K
AUID- ORCID: 0000-0002-1095-8445
AD  - Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of 
      Korea.
FAU - Al-Najjar, Mohammad A A
AU  - Al-Najjar MAA
AUID- ORCID: 0000-0003-0001-6902
AD  - Faculty of Pharmacy, Applied Science Private University, Amman 11193, Jordan.
FAU - Abdallah, Hossam M
AU  - Abdallah HM
AUID- ORCID: 0000-0003-0384-7322
AD  - Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, 
      Zagazig 44519, Egypt.
FAU - Mahmoud, Abdallah Fikry A
AU  - Mahmoud AFA
AUID- ORCID: 0000-0001-6995-0336
AD  - Food Hygiene, Safety, and Technology Department, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig 44519, Egypt.
LA  - eng
GR  - RG-20-222/Scientific Research Deanship at University of Ha'il, Saudi Arabia./
PT  - Journal Article
DEP - 20230921
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - XV74C1N1AE (hydroquinone)
RN  - 0 (Hydroquinones)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Phenols)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Animals
MH  - Hydroquinones
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Chickens
MH  - Staphylococcus aureus
MH  - *Anti-Infective Agents
MH  - Phenols/pharmacology
MH  - Anti-Bacterial Agents/pharmacology
PMC - PMC10535414
OTO - NOTNLM
OT  - Staphylococcus aureus
OT  - antimicrobials
OT  - chicken meat
OT  - foodborne pathogen
OT  - multidrug resistance
OT  - phenolic compounds
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/29 06:44
PMCR- 2023/09/21
CRDT- 2023/09/28 01:33
PHST- 2023/08/09 00:00 [received]
PHST- 2023/09/08 00:00 [revised]
PHST- 2023/09/14 00:00 [accepted]
PHST- 2023/09/29 06:44 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:33 [entrez]
PHST- 2023/09/21 00:00 [pmc-release]
AID - molecules28186742 [pii]
AID - molecules-28-06742 [pii]
AID - 10.3390/molecules28186742 [doi]
PST - epublish
SO  - Molecules. 2023 Sep 21;28(18):6742. doi: 10.3390/molecules28186742.