PMID- 37764989
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 12
IP  - 9
DP  - 2023 Sep 20
TI  - Comparison of CD4+/CD8+ Lymphocytic Subpopulations Pre- and Post-Antituberculosis 
      Treatment in Patients with Diabetes and Tuberculosis.
LID - 10.3390/pathogens12091181 [doi]
LID - 1181
AB  - Is there a CD4+ and CD8+ immunity alteration in patients with pulmonary 
      tuberculosis (TB) and diabetes (DM) that does not recover after antituberculosis 
      treatment? This prospective comparative study evaluated CD4+ and CD8+ lymphocytic 
      subpopulations and antituberculosis antibodies in patients with diabetes and 
      tuberculosis (TB-DM), before and after antituberculosis treatment. CD4+ T cell 
      counts were lower in patients with TB-DM compared to those with only TB or only 
      DM, and these levels remained low even after two months of anti-TB treatment. 
      Regarding the CD8+ T cell analysis, we identified higher blood values in the 
      DM-only group, which may be explained by the high prevalence of latent 
      tuberculosis (LTBI) in patients with DM. IgM antituberculosis antibodies levels 
      were elevated in patients with only TB at baseline, and 2 months post-anti-TB 
      treatment, IgG did not express any relevant alterations. Our results suggest an 
      alteration in CD4+ immunity in patients with TB-DM that did not normalize after 
      antituberculosis treatment.
FAU - Rendon Ramirez, Erick J
AU  - Rendon Ramirez EJ
AD  - Servicio de Neumologia y Medicina Critica, Hospital Universitario "Dr. Jose 
      Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Rosas-Taraco, Adrian G
AU  - Rosas-Taraco AG
AD  - Departamento de Inmunologia, Facultad de Medicina, Universidad Autonoma de Nuevo 
      Leon, Monterrey 64460, Mexico.
FAU - Soto-Moncivais, Berenice
AU  - Soto-Moncivais B
AUID- ORCID: 0000-0002-1903-2622
AD  - Centro de Investigacion, Prevencion y Tratamiento de Infecciones Respiratorias 
      (CIPTIR), Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Universidad 
      Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Colunga-Pedraza, Perla R
AU  - Colunga-Pedraza PR
AD  - Servicio de Hematologia, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", 
      Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Salazar-Riojas, Rosario
AU  - Salazar-Riojas R
AD  - Servicio de Hematologia, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", 
      Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Mendez-Ramirez, Nereida
AU  - Mendez-Ramirez N
AD  - Servicio de Hematologia, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", 
      Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Arce-Mendoza, Alma Yolanda
AU  - Arce-Mendoza AY
AD  - Departamento de Inmunologia, Facultad de Medicina, Universidad Autonoma de Nuevo 
      Leon, Monterrey 64460, Mexico.
FAU - Muniz-Buenrostro, Antonio
AU  - Muniz-Buenrostro A
AUID- ORCID: 0000-0002-7634-2360
AD  - Departamento de Inmunologia, Facultad de Medicina, Universidad Autonoma de Nuevo 
      Leon, Monterrey 64460, Mexico.
FAU - Llaca-Diaz, Jorge
AU  - Llaca-Diaz J
AUID- ORCID: 0000-0001-6875-2530
AD  - Departamento de Patologia Clinica, Hospital Universitario "Dr. Jose Eleuterio 
      Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Gomez-Almaguer, David
AU  - Gomez-Almaguer D
AD  - Servicio de Hematologia, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", 
      Universidad Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
FAU - Rendon, Adrian
AU  - Rendon A
AD  - Centro de Investigacion, Prevencion y Tratamiento de Infecciones Respiratorias 
      (CIPTIR), Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Universidad 
      Autonoma de Nuevo Leon, Monterrey 64460, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20230920
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC10536186
OTO - NOTNLM
OT  - QuantiFERON
OT  - active tuberculosis
OT  - adaptive immunity
OT  - diabetes
OT  - latent tuberculosis
OT  - lymphocytic subpopulations
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:43
PMCR- 2023/09/20
CRDT- 2023/09/28 01:36
PHST- 2023/07/10 00:00 [received]
PHST- 2023/09/04 00:00 [revised]
PHST- 2023/09/12 00:00 [accepted]
PHST- 2023/09/28 06:43 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:36 [entrez]
PHST- 2023/09/20 00:00 [pmc-release]
AID - pathogens12091181 [pii]
AID - pathogens-12-01181 [pii]
AID - 10.3390/pathogens12091181 [doi]
PST - epublish
SO  - Pathogens. 2023 Sep 20;12(9):1181. doi: 10.3390/pathogens12091181.