PMID- 37766101
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230930
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 11
IP  - 9
DP  - 2023 Aug 27
TI  - Anti-SARS-CoV-2 Antibody Level Is Associated with a History of COVID-19 Infection 
      and mRNA Vaccination in Patients with Diabetes.
LID - 10.3390/vaccines11091424 [doi]
LID - 1424
AB  - Type 2 diabetes mellitus (T2DM) is associated with higher severity and mortality 
      in SARS-CoV-2 infections. Vaccination has been encouraged to boost immunity and 
      prevent these unfortunate outcomes. Few studies have evaluated antibody levels 
      after COVID-19 vaccination in patients with T2DM. Therefore, we examined the 
      vaccination status and anti-SARS-CoV-2 antibody levels to identify the factors 
      that affect the antibody levels in patients with T2DM. This cross-sectional study 
      was conducted at the Dr. Hasan Sadikin Hospital and Bandung Kiwari Hospital, 
      Bandung, West Java, Indonesia, between October and November 2022. Adult 
      participants with and without T2DM were tested for SARS-CoV-2 antibodies using a 
      point-of-care quantitative immunochromatographic assay. We enrolled 289 
      participants: 201 participants with T2DM and 88 participants without T2DM. The 
      T2DM participants had a lower vaccination rate compared with the non-T2DM 
      participants. However, no significant differences in antibody levels were 
      observed between the two groups. Higher antibody levels among the T2DM 
      participants were associated with mRNA vaccination and a history of COVID-19 
      illness. The lower antibody response observed among the T2DM participants with 
      chronic obstructive pulmonary disease suggests that such patients may need 
      antibody level measurement and an additional booster vaccine.
FAU - Hataul, Is Asma'ul Haq
AU  - Hataul IAH
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
AD  - Faculty of Medicine, Universitas Pattimura, Ambon 97233, Indonesia.
FAU - Soetedjo, Nanny Natalia M
AU  - Soetedjo NNM
AUID- ORCID: 0000-0002-5735-2205
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
AD  - Division of Endocrinology and Metabolism, Internal Medicine Department, Hasan 
      Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 
      40161, Indonesia.
FAU - Debora, Josephine
AU  - Debora J
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
FAU - Tiara, Marita Restie
AU  - Tiara MR
AD  - Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas 
      Padjadjaran, Bandung 40161, Indonesia.
FAU - Djauhari, Hofiya
AU  - Djauhari H
AD  - Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas 
      Padjadjaran, Bandung 40161, Indonesia.
FAU - Susandi, Evan
AU  - Susandi E
AUID- ORCID: 0000-0002-0178-7138
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
FAU - Alisjahbana, Bachti
AU  - Alisjahbana B
AUID- ORCID: 0000-0003-3745-8229
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
AD  - Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas 
      Padjadjaran, Bandung 40161, Indonesia.
FAU - Wisaksana, Rudi
AU  - Wisaksana R
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
AD  - Research Center for Care and Control of Infectious Diseases (RC3ID), Universitas 
      Padjadjaran, Bandung 40161, Indonesia.
FAU - Permana, Hikmat
AU  - Permana H
AD  - Internal Medicine Department, Hasan Sadikin General Hospital, Faculty of 
      Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
AD  - Division of Endocrinology and Metabolism, Internal Medicine Department, Hasan 
      Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 
      40161, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20230827
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC10536458
OTO - NOTNLM
OT  - COVID-19
OT  - antibody
OT  - diabetes
OT  - humoral immunity
OT  - vaccines
COIS- The authors declare no conflict of interest.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:43
PMCR- 2023/08/27
CRDT- 2023/09/28 01:44
PHST- 2023/07/07 00:00 [received]
PHST- 2023/08/08 00:00 [revised]
PHST- 2023/08/10 00:00 [accepted]
PHST- 2023/09/28 06:43 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 01:44 [entrez]
PHST- 2023/08/27 00:00 [pmc-release]
AID - vaccines11091424 [pii]
AID - vaccines-11-01424 [pii]
AID - 10.3390/vaccines11091424 [doi]
PST - epublish
SO  - Vaccines (Basel). 2023 Aug 27;11(9):1424. doi: 10.3390/vaccines11091424.