PMID- 37766785
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 17
DP  - 2023
TI  - GABA(A) receptor availability relates to emotion-induced BOLD responses in the 
      medial prefrontal cortex: simultaneous fMRI/PET with [(11)C]flumazenil.
PG  - 1027697
LID - 10.3389/fnins.2023.1027697 [doi]
LID - 1027697
AB  - INTRODUCTION: The fMRI BOLD response to emotional stimuli highlighting the role 
      of the medial prefrontal cortex (MPFC) has been thoroughly investigated. 
      Recently, the relationship between emotion processing and GABA levels has been 
      studied using MPFC proton magnetic resonance spectroscopy (1H-MRS). However, the 
      role of GABAA receptors in the MPFC during emotion processing remains unexplored. 
      METHODS: Using [11C]flumazenil PET, we investigated the relationship between the 
      binding potential of GABAA receptors and emotion processing as measured using 
      simultaneous fMRI BOLD. We hypothesized a correlation between the percent signal 
      change in the BOLD signal and the binding potential of GABAA receptors in the 
      MPFC. In a combined simultaneous fMRI and [11C]flumazenil-PET study, we analyzed 
      the data from 15 healthy subjects using visual emotional stimuli. Our task 
      comprised two types of emotional processing: passive viewing and appraisal. 
      Following the administration of a bolus plus infusion protocol, PET and fMRI data 
      were simultaneously acquired in a hybrid 3 T MR-BrainPET. RESULTS: We found a 
      differential correlation of BOLD percent signal change with [11C]flumazenil 
      binding potential in the MPFC. Specifically, [11C]flumazenil binding potential in 
      the ventromedial prefrontal cortex (vMPFC) correlated with passive viewing of 
      emotionally valenced pictures. In contrast, the [11C]flumazenil binding potential 
      and the BOLD signal induced by picture appraisal did show a correlation in the 
      paracingulate gyrus. CONCLUSION: Our data deliver first evidence for a 
      relationship between MPFC GABAA receptors and emotion processing in the same 
      region. Moreover, we observed that GABAA receptors appear to play different roles 
      in emotion processing in the vMPFC (passive viewing) and paracingulate gyrus 
      (appraisal).
CI  - Copyright (c) 2023 Heinzel, Mauler, Herzog, Boers, Mottaghy, Langen, Scheins, 
      Lerche, Neumaier, Northoff and Shah.
FAU - Heinzel, Alexander
AU  - Heinzel A
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
AD  - Department of Nuclear Medicine, Medical Faculty RWTH Aachen, Aachen, Germany.
AD  - Department of Nuclear medicine, University Hospital Halle, Halle (Saale), 
      Germany.
FAU - Mauler, Jorg
AU  - Mauler J
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
FAU - Herzog, Hans
AU  - Herzog H
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
FAU - Boers, Frank
AU  - Boers F
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
FAU - Mottaghy, Felix M
AU  - Mottaghy FM
AD  - Department of Nuclear Medicine, Medical Faculty RWTH Aachen, Aachen, Germany.
AD  - Department of Radiology and Nuclear Medicine, Maastricht University Medical 
      Centre, Maastricht, Netherlands.
FAU - Langen, Karl-Josef
AU  - Langen KJ
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
AD  - Department of Nuclear Medicine, Medical Faculty RWTH Aachen, Aachen, Germany.
FAU - Scheins, Jurgen
AU  - Scheins J
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
FAU - Lerche, Christoph
AU  - Lerche C
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
FAU - Neumaier, Bernd
AU  - Neumaier B
AD  - Institute of Neuroscience and Medicine - 5, Forschungszentrum Julich, Julich, 
      Germany.
FAU - Northoff, Georg
AU  - Northoff G
AD  - Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health, 
      Royal Ottawa Mental Health Centre and University of Ottawa, Ottawa, ON, Canada.
FAU - Shah, N Jon
AU  - Shah NJ
AD  - Institute of Neuroscience and Medicine - 4, Forschungszentrum Julich, Julich, 
      Germany.
AD  - Institute of Neuroscience and Medicine - 11, Forschungszentrum Julich, Julich, 
      Germany.
AD  - JARA - BRAIN - Translational Medicine, Aachen, Germany.
AD  - Department of Neurology, RWTH Aachen University, Aachen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230912
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10520870
OTO - NOTNLM
OT  - BOLD signal
OT  - GABAA receptor
OT  - [11C]flumazenil
OT  - binding potential
OT  - emotion
OT  - simultaneous fMRI/PET
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/28 06:43
MHDA- 2023/09/28 06:44
PMCR- 2023/01/01
CRDT- 2023/09/28 04:00
PHST- 2022/08/25 00:00 [received]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/09/28 06:44 [medline]
PHST- 2023/09/28 06:43 [pubmed]
PHST- 2023/09/28 04:00 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2023.1027697 [doi]
PST - epublish
SO  - Front Neurosci. 2023 Sep 12;17:1027697. doi: 10.3389/fnins.2023.1027697. 
      eCollection 2023.