PMID- 37767490
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 10
DP  - 2023 Oct
TI  - Maternal stress-induced changes in adolescent and adult offspring: 
      Neurobehavioural improvement and telomere maintenance.
PG  - e20385
LID - 10.1016/j.heliyon.2023.e20385 [doi]
LID - e20385
AB  - Maternal stress (MS) during gestation is known to increase the risk for the 
      development of behavioural and physiological disorders and advances cellular 
      aging. In this study, we investigated whether the supplementation of standardized 
      Bacopa monnieri extract (CDRI-08/BME) or l-Carnosine (L-C) to the mother exposed 
      to social stress during gestation modify the effect on their offspring's 
      neurobehaviour, antioxidant defence gene expression, telomere length, and 
      telomere biology. To test this, timed pregnant rats were subjected to social 
      stress during the gestational day (GD) 16-18. A subset of stressed pregnant rats 
      received either BME [80 mg/kg in 0.5% gum acacia (per-orally; p.o)] or L-C 
      [1 mg/kg (p.o)] every day from GD-10 to until their pup's attained postnatal day 
      (PND)-23. We observed that MS induced anxiety-like behaviour, altered inter-limb 
      coordination, antioxidant defence genes [Superoxide dismutase (SOD1,2), Catalase 
      (CAT), Glutathione peroxidase-3 (GPX3)], telomerase reverse transcriptase (TERT), 
      shelterin complex subunits (TRF1, RAP1B, POT1) protein level and shorten telomere 
      length. Notably, supplementation of BME/L-C dampens the MS, thus the effect on 
      neurobehaviour, antioxidant defence gene expression, and telomere biology is 
      minimized in their offspring. Together, our results suggest that supplementation 
      of BME/L-C during gestation dampens the MS and reduced oxidative stress-mediated 
      changes in telomere shortening/biology and associated neurobehaviour in offspring 
      born following MS.
CI  - (c) 2023 The Authors.
FAU - Sivasangari, Karunanithi
AU  - Sivasangari K
AD  - Behavioural Neuroscience Laboratory, Department of Animal Science, Bharathidasan 
      University, Tiruchirappalli, India.
FAU - Sivamaruthi, Bhagavathi Sundaram
AU  - Sivamaruthi BS
AD  - Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, 
      Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
AD  - Office of Research Administration, Chiang Mai University, Chiang Mai 50200, 
      Thailand.
FAU - Chaiyasut, Chaiyavat
AU  - Chaiyasut C
AD  - Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, 
      Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
FAU - Rajan, Koilmani Emmanuvel
AU  - Rajan KE
AD  - Behavioural Neuroscience Laboratory, Department of Animal Science, Bharathidasan 
      University, Tiruchirappalli, India.
LA  - eng
PT  - Journal Article
DEP - 20230921
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10520813
OTO - NOTNLM
OT  - Anxiety-like behaviour
OT  - Bacopa monnieri
OT  - Inter-limb coordination
OT  - Maternal stress
OT  - Shelterin complex
OT  - Telomere
OT  - l- carnosine
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:43
PMCR- 2023/09/21
CRDT- 2023/09/28 04:17
PHST- 2022/12/24 00:00 [received]
PHST- 2023/07/22 00:00 [revised]
PHST- 2023/09/20 00:00 [accepted]
PHST- 2023/09/28 06:43 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 04:17 [entrez]
PHST- 2023/09/21 00:00 [pmc-release]
AID - S2405-8440(23)07593-X [pii]
AID - e20385 [pii]
AID - 10.1016/j.heliyon.2023.e20385 [doi]
PST - epublish
SO  - Heliyon. 2023 Sep 21;9(10):e20385. doi: 10.1016/j.heliyon.2023.e20385. 
      eCollection 2023 Oct.