PMID- 37767676
OWN - NLM
STAT- Publisher
LR  - 20230928
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 22
IP  - 4
DP  - 2023 Sep 3
TI  - Tumor Necrosis Factor-alpha (-308G>A) Gene Polymorphism and Its Association with 
      Asthma and Atopy Status.
PG  - 337-344
LID - 10.18502/ijaai.v22i4.13606 [doi]
AB  - Asthma is one of the most prevalent chronic lung diseases that afflict 
      genetically predisposed individuals. Certain cytokine gene polymorphisms have 
      been associated with asthma. Tumor necrosis factor-alpha (TNF-alpha) is a potent 
      inflammatory cytokine that can modulate nonspecific inflammation to influence 
      asthma. This study aimed to define the relationship between the TNF gene 
      polymorphism at position -308 and asthma susceptibility, as well as atopic and 
      non-atopic asthma. Using polymerase chain reaction with sequence-specific 
      primers, we investigated genotype frequencies and alleles of a polymorphic gene 
      coding for TNF-alpha in 86 pediatric patients with asthma and 470 healthy controls of 
      the same race. Seventy-four patients underwent a skin prick test. The homozygous 
      AA variant (-308, rs1800629) was the most common genotype among patients, 
      accounting for 63.3% of all cases. In contrast, homozygous GG (-308) was 
      significantly less prevalent in the patient group compared to the control group. 
      TNF A (-308) allele frequency was 85.5% among asthma patients and 16.6% among 
      healthy controls. The genotype and allele frequencies of TNF (-308 A>G, 
      rs1800629) did not differ between atopic and non-atopic asthma. In conclusion, 
      TNF (-308) AA and AG genotypes are associated with asthma susceptibility in 
      Iranian children, although there was no significant difference in polymorphism 
      between atopic and non-atopic asthma and no difference in asthma severity groups.
FAU - Razaghian, Anahita
AU  - Razaghian A
AD  - Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics 
      Center of Excellence, Children's Medical Center Hospital, Tehran University of 
      Medical Sciences, Tehran, Iran. anahita.razaghian@gmail.com.
FAU - Parvaneh, Nima
AU  - Parvaneh N
AD  - Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics 
      Center of Excellence, Children's Medical Center Hospital, Tehran University of 
      Medical Sciences, Tehran, Iran. nparvaneh@razi.tums.ac.ir.
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
AD  - Molecular Immunology Research Center, School of Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran AND Department of Immunology, School of Medicine, 
      Tehran University of Medical Sciences, Tehran, Iran. amirzara@tums.ac.ir.
FAU - Gharagozlou, Mohammad
AU  - Gharagozlou M
AD  - Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics 
      Center of Excellence, Children's Medical Center Hospital, Tehran University of 
      Medical Sciences, Tehran, Iran. gharagoz@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20230903
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
SB  - IM
OTO - NOTNLM
OT  - Asthma
OT  - Atopy
OT  - Gene polymorphism
OT  - PCR-SSP
OT  - Single nucleotide polymorphism
OT  - Tumor necrosis factor-alpha
EDAT- 2023/09/28 06:42
MHDA- 2023/09/28 06:42
CRDT- 2023/09/28 05:16
PHST- 2022/11/12 00:00 [received]
PHST- 2023/07/15 00:00 [accepted]
PHST- 2023/09/28 06:42 [medline]
PHST- 2023/09/28 06:42 [pubmed]
PHST- 2023/09/28 05:16 [entrez]
AID - 10.18502/ijaai.v22i4.13606 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2023 Sep 3;22(4):337-344. doi: 
      10.18502/ijaai.v22i4.13606.