PMID- 37767795
OWN - NLM
STAT- MEDLINE
DCOM- 20240418
LR  - 20240418
IS  - 1875-6360 (Electronic)
IS  - 1573-3971 (Linking)
VI  - 20
IP  - 2
DP  - 2024
TI  - Extracorporeal Shock Wave Therapy as Regenerative Medicine in Knee 
      Osteoarthritis: Pre-Experiment for Matrix Metalloproteinase-3 Evaluation.
PG  - 176-181
LID - 10.2174/0115733971230928230919053949 [doi]
AB  - BACKGROUND: Knee osteoarthritis (KOA) is currently treated by regenerative 
      therapies that aim to inhibit arthritic degeneration. Extracorporeal shock wave 
      therapy (ESWT) is one of the physical regenerative approaches used for KOA 
      management. However, little is known regarding the impact of shock wave treatment 
      on matrix metalloproteinase-3 (MMP-3), which is one of the enzymes mediating 
      cartilage degradation. OBJECTIVES: To evaluate the effect of ESWT on MMP-3 levels 
      and pain intensity in patients with KOA. METHODS: Fourteen patients diagnosed 
      with Kellgren Lawrence, grades 2 and 3 KOA were recruited for the study. ESWT 
      piezo shockwave was applied once a week for six weeks. MMP-3 levels in the blood 
      were measured pre-test, mid-test (three weeks after therapy) and post-test (one 
      week after the last session) by enzyme-linked immunosorbent assay (ELISA). The 
      perceived pain was recorded at each session by the Wong Becker Face Scale. 
      RESULTS: The median pre-test, mid-test and post-test MMP-3 levels were 19.92 
      ng/mL, 15.89 ng/mL and 18.82 ng/mL, respectively, and there were significant 
      differences between the pre-test and mid-test, and the pre-test and post-test 
      values (p < 0.05). The pain scores also decreased significantly over the period 
      of intervention. CONCLUSION: MMP-3 levels decreased significantly in KOA patients 
      after ESWT, and the decline was most obvious after 3 weeks of therapy. Therefore, 
      EWST should be considered as a suitable treatment option for KOA.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Randita, Amandha Boy Timor
AU  - Randita ABT
AUID- ORCID: 0000-0001-9739-2968
AD  - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, 
      Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 
      Indonesia.
FAU - Wardhani, Indrayuni Lukitra
AU  - Wardhani IL
AUID- ORCID: 0000-0002-9889-9039
AD  - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, 
      Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 
      Indonesia.
FAU - Andriati, Andriati
AU  - Andriati A
AD  - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, 
      Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 
      Indonesia.
FAU - Wardani, Nurul Kusuma
AU  - Wardani NK
AD  - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, 
      Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 
      Indonesia.
FAU - Philothra, Petrina Theda
AU  - Philothra PT
AD  - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, 
      Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 
      Indonesia.
FAU - Subadi, Imam
AU  - Subadi I
AUID- ORCID: 0000-0002-8575-2740
AD  - Department of Physical Medicine and Rehabilitation, Airlangga Teaching Hospital, 
      Surabaya, Indonesia.
FAU - Melaniani, Soenarnatalina
AU  - Melaniani S
AD  - Department of Epidemiology, Biostatistics, Population Studies, and Health 
      Promotion, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
LA  - eng
GR  - 1306/UN3.1.1/PT/2022/Universitas Airlangga/
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Rheumatol Rev
JT  - Current rheumatology reviews
JID - 101261938
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee/therapy
MH  - *Extracorporeal Shockwave Therapy
MH  - Matrix Metalloproteinase 3
MH  - Regenerative Medicine
MH  - Pain Measurement
OTO - NOTNLM
OT  - Knee osteoarthritis
OT  - degenerative diseases
OT  - extracorporeal shock wave therapy
OT  - kellergren lawrence.
OT  - matrix metalloproteinase-3
OT  - regenerative medicine
EDAT- 2023/09/28 12:42
MHDA- 2024/04/18 06:44
CRDT- 2023/09/28 06:34
PHST- 2022/12/01 00:00 [received]
PHST- 2023/08/01 00:00 [revised]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2024/04/18 06:44 [medline]
PHST- 2023/09/28 12:42 [pubmed]
PHST- 2023/09/28 06:34 [entrez]
AID - CRR-EPUB-134658 [pii]
AID - 10.2174/0115733971230928230919053949 [doi]
PST - ppublish
SO  - Curr Rheumatol Rev. 2024;20(2):176-181. doi: 
      10.2174/0115733971230928230919053949.