PMID- 37768924
OWN - NLM
STAT- MEDLINE
DCOM- 20231002
LR  - 20231003
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 9
DP  - 2023
TI  - Consequences of Type-2 diabetes mellitus and Malaria co-morbidity on sperm 
      parameters in men; a case-control study in a district hospital in the Ashanti 
      Region of Ghana.
PG  - e0286041
LID - 10.1371/journal.pone.0286041 [doi]
LID - e0286041
AB  - Type-2 diabetes mellitus (T2DM) and malaria infection are highly prevalent in 
      Africa particularly, in the Sub-Saharan Region. A greater number of people in the 
      Ghanaian population who have T2DM are also reported to harbor malaria parasites. 
      This study aimed to investigate the influence of T2DM & Malaria co-morbidity on 
      sperm parameters among patients in the Ashanti Region of Ghana. This 
      hospital-based cross-sectional analytic case-control study comprised 254 adult 
      male study participants comprising 80 T2DM & Malaria co-morbidity, 80 T2DM only, 
      and 94 normal controls. A blood sample (10mL) was drawn from each participant to 
      measure FBG, HbA1c levels, Testosterone levels, Total cholesterol, and 
      determination of Malaria parasite density. Seminal fluid was also collected from 
      each participant for semen analysis. Sperm kinetics of the T2DM & Malaria 
      co-morbidity group particularly; total motility, rapid progressive motility, and 
      slow progressive motility were negatively affected compared to both T2DM only 
      (p<0.0001) and the Normal control (p<0.0001). Normal sperm morphology was 
      significantly affected in the co-morbidity group compared to T2DM only 
      (p<0.0001). Sperm vitality was also statistically significantly reduced in the 
      T2DM & Malaria co-morbidity than in T2DM only (t (64) = -8.62; p<0.001). There 
      was a significant decline in testosterone levels in the T2DM & Malaria 
      co-morbidity group than in the T2DM only (p<0.0001) and the control (p <0.0001). 
      In conclusion, T2DM and malaria infection have a stronger propensity to alter 
      sperm morphology and lower sperm motility and vitality.
CI  - Copyright: (c) 2023 Abdulai et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Abdulai, Ratif
AU  - Abdulai R
AD  - Pan African University Institute of Life and Earth Sciences-Including Health and 
      Agriculture, University of Ibadan, Ibadan, Nigeria.
AD  - Department of Obstetrics and Gynaecology, College of Medicine, University of 
      Ibadan/University College Hospital, Ibadan, Nigeria.
FAU - Akwetey, Samuel Addo
AU  - Akwetey SA
AUID- ORCID: 0000-0002-8723-2271
AD  - Department of Clinical Microbiology, School of Medicine, University for 
      Development Studies, Tamale, Ghana.
FAU - Ogunbode, Olayinka Oladunjoye
AU  - Ogunbode OO
AD  - Pan African University Institute of Life and Earth Sciences-Including Health and 
      Agriculture, University of Ibadan, Ibadan, Nigeria.
AD  - Department of Obstetrics and Gynaecology, College of Medicine, University of 
      Ibadan/University College Hospital, Ibadan, Nigeria.
FAU - Aboagye, Benjamin
AU  - Aboagye B
AUID- ORCID: 0000-0002-8799-2545
AD  - Department of Forensic Sciences, School of Biological Sciences, College of 
      Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230928
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Male
MH  - Ghana/epidemiology
MH  - Semen
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Hospitals, District
MH  - Sperm Motility
MH  - Spermatozoa
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Malaria/complications/epidemiology
MH  - Testosterone
MH  - Morbidity
MH  - Sperm Count
PMC - PMC10538753
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/09/28 18:42
MHDA- 2023/10/02 06:42
PMCR- 2023/09/28
CRDT- 2023/09/28 13:34
PHST- 2023/03/09 00:00 [received]
PHST- 2023/05/08 00:00 [accepted]
PHST- 2023/10/02 06:42 [medline]
PHST- 2023/09/28 18:42 [pubmed]
PHST- 2023/09/28 13:34 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - PONE-D-23-06530 [pii]
AID - 10.1371/journal.pone.0286041 [doi]
PST - epublish
SO  - PLoS One. 2023 Sep 28;18(9):e0286041. doi: 10.1371/journal.pone.0286041. 
      eCollection 2023.