PMID- 3776916
OWN - NLM
STAT- MEDLINE
DCOM- 19861205
LR  - 20190511
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 86
IP  - 5
DP  - 1986 Nov
TI  - Association of hereditary spherocytosis and idiopathic hemochromatosis. A 
      synergistic effect in determining iron overload.
PG  - 645-9
AB  - Two siblings, both splenectomized at an early age for hereditary spherocytosis, 
      had a severe hemochromatosis develop. The human leukocyte antigen (HLA) system 
      typing showed that they were half HLA identical. All the other members of the 
      family who did not have evidence of hereditary spherocytosis, including those who 
      displayed identical HLA haplotypes with the two patients, did not have any 
      increase in iron stores. These results suggest that the two siblings are 
      heterozygous for idiopathic hemochromatosis and that the coexistence of this 
      condition with hereditary spherocytosis can cause a severe iron overload.
FAU - Fargion, S
AU  - Fargion S
FAU - Cappellini, M D
AU  - Cappellini MD
FAU - Piperno, A
AU  - Piperno A
FAU - Panajotopoulos, N
AU  - Panajotopoulos N
FAU - Ronchi, G
AU  - Ronchi G
FAU - Fiorelli, G
AU  - Fiorelli G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (HLA Antigens)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Female
MH  - HLA Antigens/genetics
MH  - Hemochromatosis/*complications/genetics
MH  - Heterozygote
MH  - Humans
MH  - Iron/blood
MH  - Liver Function Tests
MH  - Male
MH  - Pedigree
MH  - Spherocytosis, Hereditary/*complications/genetics/immunology
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
AID - 10.1093/ajcp/86.5.645 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 1986 Nov;86(5):645-9. doi: 10.1093/ajcp/86.5.645.