PMID- 37769240
OWN - NLM
STAT- Publisher
LR  - 20230928
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Linking)
DP  - 2023 Sep 25
TI  - Retinal Pigment Epithelial Detachments Devoid of Retinal Pigment Epithelium.
LID - 10.1097/ICB.0000000000001499 [doi]
AB  - PURPOSE: To describe two patients with chronic central serous chorioretinopathy 
      (CSC) showing what appeared to be retinal pigment epithelium detachments (PED) 
      lacking imaging findings consistent with retinal pigment epithelium (RPE) over 
      the elevation. METHOD: The patients underwent comprehensive ophthalmic 
      examination, including multicolor fundus photography, fundus autofluorescence 
      (FAF), and spectral-domain optical coherence tomography (SD-OCT). RESULTS: A 
      70-year-old male and a 58-year-old male, both diagnosed with chronic CSC, showed 
      PED-like lesions that were hypoautofluorescent, suggesting an absence of RPE. 
      SD-OCT B-scans showed serous, dome-shaped elevations composed of a narrow, mildly 
      hyperreflective band (9-10 mum thick) that demonstrated hypertransmission of 
      light. The material that constituted the elevation was contiguous with the outer 
      portion of the RPE band at the lesion borders. CONCLUSION: Based on the 
      multimodal imaging findings we hypothesize that these elevations of the retina 
      have lost their overlying RPE. A thin layer of material that could represent a 
      residual layer of basal laminar deposit produced by the RPE remains overlying the 
      detachments, possibly accounting for their dome shape and structural stability.
FAU - Salcedo-Ledesma, Alfredo
AU  - Salcedo-Ledesma A
AD  - Vitreous Retina Macula Consultants of New York, New York, USA.
FAU - Ledesma-Gil, Gerardo
AU  - Ledesma-Gil G
FAU - Keshet, Yariv
AU  - Keshet Y
FAU - Spaide, Richard F
AU  - Spaide RF
LA  - eng
PT  - Journal Article
DEP - 20230925
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
SB  - IM
EDAT- 2023/09/29 00:42
MHDA- 2023/09/29 00:42
CRDT- 2023/09/28 19:06
PHST- 2023/09/29 00:42 [medline]
PHST- 2023/09/29 00:42 [pubmed]
PHST- 2023/09/28 19:06 [entrez]
AID - 01271216-990000000-00233 [pii]
AID - 10.1097/ICB.0000000000001499 [doi]
PST - aheadofprint
SO  - Retin Cases Brief Rep. 2023 Sep 25. doi: 10.1097/ICB.0000000000001499.