PMID- 37769240
OWN - NLM
STAT- MEDLINE
DCOM- 20241218
LR  - 20250211
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Linking)
VI  - 19
IP  - 1
DP  - 2025 Jan 1
TI  - RETINAL PIGMENT EPITHELIAL DETACHMENTS DEVOID OF RETINAL PIGMENT EPITHELIUM.
PG  - 1-4
LID - 10.1097/ICB.0000000000001499 [doi]
AB  - PURPOSE: To describe two patients with chronic central serous chorioretinopathy 
      showing what appeared to be retinal pigment epithelium detachments lacking 
      imaging findings consistent with retinal pigment epithelium (RPE) over the 
      elevation. METHODS: The patients underwent comprehensive ophthalmic examination, 
      including multicolor fundus photography, fundus autofluorescence, and 
      spectral-domain optical coherence tomography. RESULTS: A 70-year-old man and a 
      58-year-old man, diagnosed with chronic central serous chorioretinopathy, showed 
      pigment epithelium detachment-like lesions that were hypoautofluorescent, 
      suggesting an absence of RPE. Spectral-domain optical coherence tomography B 
      scans showed serous, dome-shaped elevations composed of a narrow, mildly 
      hyperreflective band (9-10- micro m thick) that demonstrated hypertransmission of 
      light. The material that constituted the elevation was contiguous with the outer 
      portion of the RPE band at the lesion borders. CONCLUSION: Based on the 
      multimodal imaging findings, we hypothesize that these pigment epithelial 
      detachments have lost the RPE. A thin layer of material that could represent a 
      residual layer of basal laminar deposit produced by the RPE remains overlying the 
      detachments, possibly accounting for their dome shape and structural stability.
FAU - Salcedo-Ledesma, Alfredo
AU  - Salcedo-Ledesma A
AD  - Vitreous Retina Macula Consultants of New York, New York, New York.
FAU - Ledesma-Gil, Gerardo
AU  - Ledesma-Gil G
FAU - Keshet, Yariv
AU  - Keshet Y
FAU - Spaide, Richard F
AU  - Spaide RF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
SB  - IM
MH  - Humans
MH  - *Retinal Detachment/diagnosis/etiology
MH  - Male
MH  - *Retinal Pigment Epithelium/pathology
MH  - Aged
MH  - Middle Aged
MH  - *Tomography, Optical Coherence/methods
MH  - *Central Serous Chorioretinopathy/diagnosis
MH  - *Fluorescein Angiography/methods
MH  - Visual Acuity
MH  - Fundus Oculi
EDAT- 2023/09/29 00:42
MHDA- 2024/12/18 18:21
CRDT- 2023/09/28 19:06
PHST- 2024/12/18 18:21 [medline]
PHST- 2023/09/29 00:42 [pubmed]
PHST- 2023/09/28 19:06 [entrez]
AID - 01271216-202501000-00001 [pii]
AID - 10.1097/ICB.0000000000001499 [doi]
PST - ppublish
SO  - Retin Cases Brief Rep. 2025 Jan 1;19(1):1-4. doi: 10.1097/ICB.0000000000001499.