PMID- 37769449
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231030
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 461
DP  - 2024 Jan 5
TI  - Unveiling the metal mutation nexus: Exploring the genomic impacts of heavy metal 
      exposure in lung adenocarcinoma and colorectal cancer.
PG  - 132590
LID - S0304-3894(23)01873-3 [pii]
LID - 10.1016/j.jhazmat.2023.132590 [doi]
AB  - Mutations that activate oncogenes and deactivate tumor suppressor genes are 
      widely recognized as significant contributors to cancer development. We 
      investigated relationships between heavy metal exposure and the frequencies and 
      types of gene mutations in patients with lung adenocarcinoma (LUAD) and 
      colorectal cancer (CRC). Plasma concentrations of arsenic (As), cadmium (Cd), 
      chromium (Cr), mercury (Hg), and lead (Pb) were measured using inductively 
      coupled plasma mass spectrometry (ICPMS), and next-generation sequencing (NGS) of 
      1123 cancer-related genes was performed using the tumor tissues. Through Bayesian 
      kernel machine regression (BKMR) analysis, we found associations between the 
      integrated concentrations of the heavy metals and the number of gene mutations, 
      especially insertions/deletions (indels), and Pb, As, and Cd were found to be the 
      most significant contributors to the increased mutation rates. We extracted 
      previously established mutational signatures and observed that they exhibit 
      significant correlations with metal exposure. Moreover, we detected substantial 
      shifts in the mutational landscape when comparing groups with high and low metal 
      exposures. Several frequently mutated genes displayed positive correlations with 
      metal exposure, whereas EGFR indels showed a negative association with Cd 
      exposure. These findings suggest that heavy metal exposure can impact genomic 
      stability in cancer-related genes, underscoring the importance of heavy metal 
      exposure in cancer development.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Liu, Mengyuan
AU  - Liu M
AD  - Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, 
      China; WillingMed Technology (Beijing) Co., Ltd, Beijing 100176, China; Beijing 
      ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Hong, Yuting
AU  - Hong Y
AD  - Department of Epidemiology, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing 100021, China.
FAU - Duan, Xiaohong
AU  - Duan X
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Zhou, Qiming
AU  - Zhou Q
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Liu, Siyao
AU  - Liu S
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Su, Junyan
AU  - Su J
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Han, Li
AU  - Han L
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Zhang, Jiali
AU  - Zhang J
AD  - Beijing ChosenMed Clinical Laboratory Co., Ltd., Beijing 100176, China.
FAU - Niu, Beifang
AU  - Niu B
AD  - Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, 
      China; School of Computer Science, University of the Chinese Academy of Sciences, 
      Beijing 100190, China. Electronic address: niubf@cnic.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230922
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - 0 (Metals, Heavy)
RN  - N712M78A8G (Arsenic)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Humans
MH  - Cadmium/analysis
MH  - Bayes Theorem
MH  - Lead/toxicity
MH  - *Metals, Heavy/toxicity/analysis
MH  - *Arsenic/analysis
MH  - *Mercury/analysis
MH  - *Adenocarcinoma of Lung/genetics
MH  - Genomics
MH  - *Lung Neoplasms/chemically induced/genetics
MH  - Mutation
MH  - *Colorectal Neoplasms/genetics
OTO - NOTNLM
OT  - Cancer-related genes
OT  - Heavy metal elements
OT  - Insertions/deletions
OT  - Single nucleotide variations
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/09/29 00:42
MHDA- 2023/10/23 01:18
CRDT- 2023/09/28 19:17
PHST- 2023/07/13 00:00 [received]
PHST- 2023/09/06 00:00 [revised]
PHST- 2023/09/19 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/09/29 00:42 [pubmed]
PHST- 2023/09/28 19:17 [entrez]
AID - S0304-3894(23)01873-3 [pii]
AID - 10.1016/j.jhazmat.2023.132590 [doi]
PST - ppublish
SO  - J Hazard Mater. 2024 Jan 5;461:132590. doi: 10.1016/j.jhazmat.2023.132590. Epub 
      2023 Sep 22.