PMID- 37770872
OWN - NLM
STAT- MEDLINE
DCOM- 20231004
LR  - 20231121
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 24
IP  - 1
DP  - 2023 Sep 28
TI  - Kidney function decline associated with proton pump inhibitors: results from the 
      ELSA-Brasil cohort.
PG  - 285
LID - 10.1186/s12882-023-03300-4 [doi]
LID - 285
AB  - OBJECTIVE: Investigate the longitudinal association of use and time of use of 
      proton pump inhibitors (PPI) with incidence of chronic kidney disease (CKD) and 
      kidney function change. METHODS: Prospective study with 13,909 participants from 
      baseline (2008-2010) and second wave (2012-2014) of the ELSA-Brasil (mean 
      interval between visits = 3.9 years (1.7-6.0)). Participants answered about use 
      and time use of the PPI in the two weeks prior the interview. Renal function was 
      assessed by glomerular filtration rate estimated by the Collaboration Equation 
      for the Epidemiology of Chronic Kidney Disease. Values below 60ml/min/1.73 m(2) in 
      wave 2 were considered incident CKD. Associations between PPI use and time of use 
      at baseline and incident CKD and decline in renal function were estimated, 
      respectively, by logistic regression and linear models with mixed effects, after 
      adjusting for confounders. RESULTS: After adjustments, PPI users for more than 
      six months had an increased risk of CKD compared to non-users. Compared to 
      non-users, users PPIs for up to six months and above six months had greater 
      decline in kidney function over time. CONCLUSION: This cohort of adults and 
      elderly, after a mean interval of 3.9 years, PPI use and initial duration were 
      associated with kidney function change between visits.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Dos Santos, Andreza Soares
AU  - Dos Santos AS
AD  - Postgraduate Program in Health Sciences, Universidade Federal de Sao Joao 
      del-Rei, Sebastiao Goncalves Coelho Street, 400 - Chanadour, Divinopolis, 
      35501-296, MG, Brazil.
FAU - de Menezes, Sara Teles
AU  - de Menezes ST
AD  - Longitudinal Study of Adult Health - ELSA-Brasil, Medical School & Clinical 
      Hospital/EBSERH, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 
      Brazil.
FAU - Silva, Isabella Ribeiro
AU  - Silva IR
AD  - Postgraduate Program in Health Sciences, Universidade Federal de Sao Joao 
      del-Rei, Sebastiao Goncalves Coelho Street, 400 - Chanadour, Divinopolis, 
      35501-296, MG, Brazil.
FAU - Oliveira, William Neves
AU  - Oliveira WN
AD  - Postgraduate Program in Health Sciences, Universidade Federal de Sao Joao 
      del-Rei, Sebastiao Goncalves Coelho Street, 400 - Chanadour, Divinopolis, 
      35501-296, MG, Brazil.
FAU - Pereira, Mariana Linhares
AU  - Pereira ML
AD  - Postgraduate Program in Health Sciences, Universidade Federal de Sao Joao 
      del-Rei, Sebastiao Goncalves Coelho Street, 400 - Chanadour, Divinopolis, 
      35501-296, MG, Brazil.
FAU - Mill, Jose Geraldo
AU  - Mill JG
AD  - Department of Physiological Sciences & University Hospital, Universidade Federal 
      do Espirito Santo, Vitoria, Brazil.
FAU - Barreto, Sandhi Maria
AU  - Barreto SM
AD  - Medical School & Clinical Hospital/EBSERH, Universidade Federal de Minas Gerais, 
      Belo Horizonte, MG, Brazil.
FAU - Figueiredo, Roberta Carvalho
AU  - Figueiredo RC
AD  - Postgraduate Program in Health Sciences, Universidade Federal de Sao Joao 
      del-Rei, Sebastiao Goncalves Coelho Street, 400 - Chanadour, Divinopolis, 
      35501-296, MG, Brazil. robertafigueiredo@ufsj.edu.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230928
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Aged
MH  - *Proton Pump Inhibitors/adverse effects
MH  - Prospective Studies
MH  - *Renal Insufficiency, Chronic
MH  - Glomerular Filtration Rate
MH  - Kidney
MH  - Risk Factors
PMC - PMC10538238
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Kidney function
OT  - Pharmacoepidemiology
OT  - Pharmacovigilance
OT  - Proton pump inhibitors
COIS- The authors declare no competing interests. The authors declare no conflict of 
      interest.
EDAT- 2023/09/29 00:42
MHDA- 2023/10/04 06:43
PMCR- 2023/09/28
CRDT- 2023/09/28 23:48
PHST- 2023/03/10 00:00 [received]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/10/04 06:43 [medline]
PHST- 2023/09/29 00:42 [pubmed]
PHST- 2023/09/28 23:48 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - 10.1186/s12882-023-03300-4 [pii]
AID - 3300 [pii]
AID - 10.1186/s12882-023-03300-4 [doi]
PST - epublish
SO  - BMC Nephrol. 2023 Sep 28;24(1):285. doi: 10.1186/s12882-023-03300-4.