PMID- 37771671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 10
DP  - 2023
TI  - Safety and efficacy of His-Purkinje system pacing in the treatment of patients 
      with atrial fibrillation and heart failure: a systematic review and 
      meta-analysis.
PG  - 1233694
LID - 10.3389/fcvm.2023.1233694 [doi]
LID - 1233694
AB  - AIM: To evaluate the safety and efficacy of the His-Purkinje system pacing 
      (HPCSP) in the treatment of individuals with atrial fibrillation (AF) complicated 
      by heart failure (HF). METHODS: The PubMed, Cochrane Library, Web of Science, and 
      Embase databases were searched through September 1, 2022. The literature was 
      initially screened based on the inclusion and exclusion criteria. The baseline 
      characteristics of the subjects, implantation success rate, New York Heart 
      Association (NYHA) classification, left ventricular ejection fraction (LVEF), 
      left ventricular end-diastolic diameter (LVEDd), QRS duration, pacing threshold, 
      and impedance were extracted and summarized; statistical analysis was performed 
      using RevMan 5.3 software. RESULTS: In all, 22 articles were included, involving 
      1,445 patients. Compared to biventricular pacing (BiVP), HPCSP resulted in 
      improved cardiac function, including increased ejection fraction (MD = 5.69, 95% 
      CI: 0.78-10.60, P = 0.02) and decreased LVEDd (MD = -3.50, 95% CI: -7.05-0.05, 
      P = 0.05). It was also correlated with shorter QRS duration (MD = -38.30, 95% CI: 
      -60.71--15.88, P < 0.01) and reduced all-cause mortality and rehospitalization 
      events (RR = 0.72, 95% CI: 0.57-0.91, P < 0.01) in patients. Left bundle branch 
      pacing (LBBP) lowered the pacing threshold (MD = 0.47; 95% CI: 0.25-0.69; 
      P < 0.01), and there was no statistical difference in the rate of endpoint events 
      when comparing these two physiologic pacing modalities (RR = 1.56, 95% CI: 
      0.87-2.80, P = 0.14). CONCLUSION: The safety and efficacy of HPCSP in patients 
      with AF and HF were verified in this meta-analysis. HPCSP can reverse cardiac 
      remodeling and has great clinical application value. Relatively speaking, 
      His-bundle pacing (HBP) can maintain better ventricular electro-mechanical 
      synchronization, and the pacing parameters of LBBP are more stable. SYSTEMATIC 
      REVIEW REGISTRATION: PROSPERO (CRD42022336109).
CI  - (c) 2023 Guan, Wang, Guan, Cheng and Sun.
FAU - Guan, Lin
AU  - Guan L
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Wang, Chuanhe
AU  - Wang C
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Guan, Xueqing
AU  - Guan X
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Cheng, Gong
AU  - Cheng G
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Sun, Zhijun
AU  - Sun Z
AD  - Department of Cardiology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230913
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC10525682
OTO - NOTNLM
OT  - His bundle pacing
OT  - His-Purkinje system pacing
OT  - atrial fibrillation
OT  - heart failure
OT  - left bundle branch pacing
OT  - meta-analysis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/09/29 06:44
MHDA- 2023/09/29 06:45
PMCR- 2023/01/01
CRDT- 2023/09/29 03:53
PHST- 2023/06/02 00:00 [received]
PHST- 2023/08/29 00:00 [accepted]
PHST- 2023/09/29 06:45 [medline]
PHST- 2023/09/29 06:44 [pubmed]
PHST- 2023/09/29 03:53 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2023.1233694 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2023 Sep 13;10:1233694. doi: 10.3389/fcvm.2023.1233694. 
      eCollection 2023.