PMID- 37773081
OWN - NLM
STAT- MEDLINE
DCOM- 20231004
LR  - 20231121
IS  - 2047-783X (Electronic)
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 28
IP  - 1
DP  - 2023 Sep 29
TI  - Relationship between cortisol and diabetic microvascular complications: a 
      retrospective study.
PG  - 391
LID - 10.1186/s40001-023-01325-x [doi]
LID - 391
AB  - OBJECTIVE: We aimed to investigate whether serum cortisol associate with diabetic 
      microvascular compliments in patients with type 2 diabetes mellitus (T2DM). 
      MATERIALS AND METHODS: The subjects were recruited from hospitalized patients 
      with T2DM from 2019 to 2021. The odds ratios (OR) and corresponding 95% 
      confidence intervals (CI) in relation to cortisol quartiles were obtained by 
      multiple logistic regression analysis. RESULTS: (1) Cortisol level was positively 
      correlated with the severity of microalbuminuria. The OR (95% CI) of 
      microalbuminuria and macroalbuminuria in the last quartile were 3.396 (2.030, 
      5.682) and 8.407 (3.726, 18.971) compared with the first quartile (p < 0.001). 
      (2) Cortisol level was positively correlated with the severity of diabetic 
      retinopathy (DR). The OR (95% CI) of non-proliferative diabetic retinopathy group 
      (NPDR) and proliferative diabetic retinopathy group (PDR) in the last quartile 
      were 2.007 (1.401, 2.875) and 7.122 (2.525, 20.090) compared with the first 
      quartile. (3) Elevated cortisol level was associated with diabetic peripheral 
      neuropathy. The OR (95% CI) of diabetic peripheral neuropathy (DPN) in the last 
      quartile was 1.956 (1.371, 2.792) and that in the third quartile was 1.854 
      (1.319, 2.608). CONCLUSIONS: High serum cortisol levels were significantly 
      associated with diabetic microvascular compliments in inpatients. Its causality 
      remains to be further studied. CLINICAL TRIAL REGISTRATION NUMBER: 
      ChiCTR2100051749.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Sun, Shengnan
AU  - Sun S
AD  - The Affiliated Hospital of Qingdao University, Qingdao, China.
AD  - Tianjin Medical University, Tianjin, 300134, China.
FAU - Wang, Yangang
AU  - Wang Y
AD  - The Affiliated Hospital of Qingdao University, Qingdao, China. 
      wangyg1966@126.com.
LA  - eng
PT  - Journal Article
DEP - 20230929
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Retrospective Studies
MH  - Hydrocortisone
MH  - *Diabetic Neuropathies/complications
PMC - PMC10543849
OTO - NOTNLM
OT  - Cortisol
OT  - Diabetic microvascular complication
OT  - Logistic regression analysis
OT  - Type 2 diabetes
COIS- The authors declare they have no competing interests.
EDAT- 2023/09/29 12:43
MHDA- 2023/10/04 06:43
PMCR- 2023/09/29
CRDT- 2023/09/29 11:22
PHST- 2022/12/15 00:00 [received]
PHST- 2023/08/27 00:00 [accepted]
PHST- 2023/10/04 06:43 [medline]
PHST- 2023/09/29 12:43 [pubmed]
PHST- 2023/09/29 11:22 [entrez]
PHST- 2023/09/29 00:00 [pmc-release]
AID - 10.1186/s40001-023-01325-x [pii]
AID - 1325 [pii]
AID - 10.1186/s40001-023-01325-x [doi]
PST - epublish
SO  - Eur J Med Res. 2023 Sep 29;28(1):391. doi: 10.1186/s40001-023-01325-x.