PMID- 37774702
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20240124
IS  - 2213-6711 (Electronic)
IS  - 2213-6711 (Linking)
VI  - 18
IP  - 10
DP  - 2023 Oct 10
TI  - Creating an HLA-homozygous iPS cell bank for the Brazilian population: Challenges 
      and opportunities.
PG  - 1905-1912
LID - S2213-6711(23)00336-3 [pii]
LID - 10.1016/j.stemcr.2023.09.001 [doi]
AB  - Identifying human leukocyte antigen (HLA) haplotype-homozygous donors for the 
      generation of induced pluripotent stem (iPS) cell lines permits the construction 
      of biobanks immunologically compatible with significant numbers of individuals 
      for use in therapy. However, two questions must be addressed to create such a 
      bank: how many cell lines are necessary to match most of the recipient population 
      and how many people should be tested to find these donors? In Japan and the UK, 
      50 and 100 distinct HLA-A, -B, and -DRB1 triple-homozygous haplotypes would cover 
      90% of those populations, respectively. Using data from the Brazilian National 
      Registry of Bone Marrow Donors (REDOME), encompassing 4,017,239 individuals, we 
      identified 1,906 distinct triple-homozygous HLA haplotypes. In Brazil, 559 
      triple-homozygous cell lines cover 95% of the population, and 3.8 million people 
      would have to be screened. Finally, we show the contribution of the 30 most 
      frequent triple-homozygous HLA haplotypes in Brazil to populations of different 
      countries.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Martins de Oliveira, Marcio Lassance
AU  - Martins de Oliveira ML
AD  - Department of Biostatistics and Bioinformatics of National Institute of 
      Cardiology, Ministry of Health, Rio de Janeiro, Brazil. Electronic address: 
      lassance.ncc1701@gmail.com.
FAU - Tura, Bernardo Rangel
AU  - Tura BR
AD  - Department of Biostatistics and Bioinformatics of National Institute of 
      Cardiology, Ministry of Health, Rio de Janeiro, Brazil.
FAU - Meira Leite, Mauro
AU  - Meira Leite M
AD  - Genetics of Complex Diseases Laboratory, Federal University of Para, Belem, 
      Brazil.
FAU - Melo Dos Santos, Eduardo Jose
AU  - Melo Dos Santos EJ
AD  - Genetics of Complex Diseases Laboratory, Federal University of Para, Belem, 
      Brazil.
FAU - Porto, Luis Cristovao
AU  - Porto LC
AD  - Histocompatibility and Cryopreservation Laboratory - Rio de Janeiro State 
      University (UERJ), Rio de Janeiro, Brazil.
FAU - Pereira, Lygia V
AU  - Pereira LV
AD  - Department of Genetics and Evolutionary Biology, Institute of Biosciences of 
      University of Sao Paulo (USP), Sao Paulo, Brazil.
FAU - Campos de Carvalho, Antonio Carlos
AU  - Campos de Carvalho AC
AD  - Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro 
      (UFRJ) - Cellular and Molecular Cardiology Laboratory, Rio de Janeiro, Brazil; 
      National Institute for Science and Technology in Regenerative Medicine, Rio de 
      Janeiro, Brazil. Electronic address: acarlos@biof.ufrj.br.
LA  - eng
PT  - Journal Article
DEP - 20230928
PL  - United States
TA  - Stem Cell Reports
JT  - Stem cell reports
JID - 101611300
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - Brazil
MH  - *Induced Pluripotent Stem Cells/metabolism
MH  - HLA Antigens/metabolism
MH  - HLA-A Antigens/genetics/metabolism
MH  - Tissue Donors
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Alleles
MH  - Gene Frequency
PMC - PMC10656352
OTO - NOTNLM
OT  - Brazil
OT  - HLA
OT  - REDOME
OT  - haplobank
OT  - iPS Biobank
OT  - iPSC
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2023/09/30 09:42
MHDA- 2023/11/27 12:43
PMCR- 2023/09/28
CRDT- 2023/09/29 18:41
PHST- 2022/05/20 00:00 [received]
PHST- 2023/08/31 00:00 [revised]
PHST- 2023/09/01 00:00 [accepted]
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/09/30 09:42 [pubmed]
PHST- 2023/09/29 18:41 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - S2213-6711(23)00336-3 [pii]
AID - 10.1016/j.stemcr.2023.09.001 [doi]
PST - ppublish
SO  - Stem Cell Reports. 2023 Oct 10;18(10):1905-1912. doi: 
      10.1016/j.stemcr.2023.09.001. Epub 2023 Sep 28.