PMID- 37775007 OWN - NLM STAT- MEDLINE DCOM- 20231108 LR - 20231108 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 238 IP - Pt 2 DP - 2023 Dec 1 TI - Association between per- and polyfluoroalkyl substances (PFAS) and depression in U.S. adults: A cross-sectional study of NHANES from 2005 to 2018. PG - 117188 LID - S0013-9351(23)01992-8 [pii] LID - 10.1016/j.envres.2023.117188 [doi] AB - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants (POPs) associated with diseases including osteoporosis, altered immune function and cancer. However, few studies have investigated the association between PFAS mixture exposure and Depression in general populations. METHODS: Nationally representative data from the National Health and Nutrition Examination Survey (NHANES) (2005-2018) were used to analyze the association between PFAS and Depression in U.S. adults. Total 12,239 adults aged 20 years or older who had serum PFAS measured and answered Patient Health Questionnaire-9 (PHQ-9) were enrolled in this study. PFAS monomers detected in all 7 investigation cycles were included in the study. Generalized additive model (GAM) was used to fit smooth curves and threshold effect analysis was carried out to find the turning point of smooth curves. Generalized linear model (GLM) was used to describe the non-linear relationship between PFAS and depression and unconditioned logistic regression was used to risk analysis. RESULTS: The median of total serum PFAS concentration was 14.54 ng/mL. The curve fitting results indicated a U-shaped relationship between total serum PFAS and depression: PFAS< 39.66 ng/mL, A negative correlation between PHQ-9 score and serum PFAS concentration was observed (beta 0.047,95%CI -0.059, -0.036). The depression PHQ-9 score decreased with the increase of serum PFAS concentration. PFAS >/= 39.66 ng/mL, A positive correlation was observed between PFAS and PHQ-9 score (beta 0.010,95% CI 0.003, 0.017). The depression PHQ-9 score increased with the increase of serum PFAS concentration. CONCLUSIONS: Our study provides new clues to the association of PFAS with depression, and large population-based cohort studies that can validate the causal association as well as toxicological mechanism studies are needed for validation. CI - Copyright (c) 2023 Elsevier Inc. All rights reserved. FAU - Yi, Wensen AU - Yi W AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: 3052832588@qq.com. FAU - Xuan, Lihui AU - Xuan L AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: 226901009@csu.edu.cn. FAU - Zakaly, Hesham M H AU - Zakaly HMH AD - Experimental Physics Department, Institute of Physics and Technology, Ural Federal University, Ekaterinburg, Russia. Electronic address: h.m.zakaly@gmail.com. FAU - Markovic, Vladimir AU - Markovic V AD - Faculty of Science, University of Kragujevac, Serbia. Electronic address: vmarkovic@kg.ac.rs. FAU - Miszczyk, Justyna AU - Miszczyk J AD - Department of Medical Physics, Cyclotron Centre Bronowice, Institute of Nuclear Physics Polish Academy of Sciences, PL-31342, Krakow, Poland. FAU - Guan, Hua AU - Guan H AD - Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, 100850, China. Electronic address: ghlsh@163.com. FAU - Zhou, Ping-Kun AU - Zhou PK AD - Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, 100850, China. Electronic address: zhoupk@bmi.ac.cn. FAU - Huang, Ruixue AU - Huang R AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: huangruixue@csu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230927 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Environmental Pollutants) RN - 0 (Alkanesulfonic Acids) RN - 0 (Fluorocarbons) SB - IM MH - Humans MH - Adult MH - *Environmental Pollutants MH - *Alkanesulfonic Acids MH - Cross-Sectional Studies MH - Nutrition Surveys MH - Depression MH - *Fluorocarbons OTO - NOTNLM OT - Depression OT - NHANES OT - Per- and polyfluoroalkyl substances COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/09/30 09:42 MHDA- 2023/11/08 06:43 CRDT- 2023/09/29 19:18 PHST- 2023/08/05 00:00 [received] PHST- 2023/09/18 00:00 [revised] PHST- 2023/09/22 00:00 [accepted] PHST- 2023/11/08 06:43 [medline] PHST- 2023/09/30 09:42 [pubmed] PHST- 2023/09/29 19:18 [entrez] AID - S0013-9351(23)01992-8 [pii] AID - 10.1016/j.envres.2023.117188 [doi] PST - ppublish SO - Environ Res. 2023 Dec 1;238(Pt 2):117188. doi: 10.1016/j.envres.2023.117188. Epub 2023 Sep 27.