PMID- 37775917
OWN - NLM
STAT- MEDLINE
DCOM- 20231030
LR  - 20231112
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 102
IP  - 12
DP  - 2023 Nov
TI  - Butyrate Inhibits Dendritic Cell Activation and Alleviates Periodontitis.
PG  - 1326-1336
LID - 10.1177/00220345231187824 [doi]
AB  - Dendritic cells (DCs) can mediate inflammation-related bone resorption that is 
      crucial in the development of periodontitis. Butyrate is a critical by-product of 
      microbes with antibacterial and anti-inflammatory properties. Here, we found that 
      butyrate inhibited the activation of lipopolysaccharide (LPS)-induced DCs and 
      generation of inflammatory cytokines by DCs. Moreover, butyrate regulated 
      glycolysis in LPS-induced DCs via the G-protein-coupled 
      receptor/hypoxia-inducible factor-1alpha pathway. In addition, butyrate inhibited the 
      maturation of CD11c(+)MHC-II(+) DCs in vivo, suppressing local inflammatory 
      infiltration and ultimately alleviating bone resorption in a periodontitis model. 
      Our results imply that butyrate suppresses the activation of LPS-induced DCs by 
      modulating their metabolism, highlighting its potential as a therapeutic agent 
      for inflammatory diseases.
FAU - Wu, L
AU  - Wu L
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Luo, Z
AU  - Luo Z
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Chen, Y
AU  - Chen Y
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Yan, Z
AU  - Yan Z
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Fu, J
AU  - Fu J
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Jiang, Y
AU  - Jiang Y
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Xu, J
AU  - Xu J
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
FAU - Liu, Y
AU  - Liu Y
AD  - Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, 
      Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, P. R. China.
AD  - Immunology Research Center for Oral and Systemic Health, Beijing Friendship 
      Hospital, Capital Medical University, Beijing, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230929
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Butyrates)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - Butyrates/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Dendritic Cells
MH  - Cytokines/metabolism
MH  - *Periodontitis/drug therapy/metabolism
MH  - *Bone Resorption/metabolism
OTO - NOTNLM
OT  - Hif1alpha
OT  - butyrate
OT  - dendritic cells
OT  - glycolysis
OT  - periodontitis
COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/09/30 09:42
MHDA- 2023/10/30 06:46
CRDT- 2023/09/30 00:23
PHST- 2023/10/30 06:46 [medline]
PHST- 2023/09/30 09:42 [pubmed]
PHST- 2023/09/30 00:23 [entrez]
AID - 10.1177/00220345231187824 [doi]
PST - ppublish
SO  - J Dent Res. 2023 Nov;102(12):1326-1336. doi: 10.1177/00220345231187824. Epub 2023 
      Sep 29.