PMID- 37776820 OWN - NLM STAT- Publisher LR - 20231012 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 265 DP - 2023 Oct 15 TI - Higher HDL-C levels attenuated the association of plasma polybrominated diphenyl ethers with prediabetes and type 2 diabetes mellitus in rural Chinese adults. PG - 115524 LID - S0147-6513(23)01028-X [pii] LID - 10.1016/j.ecoenv.2023.115524 [doi] AB - BACKGROUND: Plasma polybrominated diphenyl ethers (PBDE) were used as flame retardants widely, however, epidemiological evidence for the association between PBDEs and type 2 diabetes mellitus (T2DM) is inconsistent. Moreover, the combined effects of PBDEs and blood lipid indicators on impaired fasting glucose (IFG) and T2DM remains largely unknown in rural areas lacking good waste recycling infrastructure. METHODS: In this study, a total of 2607 subjects aged 18-79 years were included from the Henan Rural Cohort. Generalized linear and logistic regression models were applied to evaluate the associations of various PBDE pollutants on IFG and T2DM. Quantile g-computation regression and PBDE pollution score created by the adaptive elastic net were applied to evaluate the impact of PBDEs mixtures on IFG and T2DM. Interaction effects of individual PBDE pollutants and blood lipid indicators on IFG and T2DM were assessed by using Interaction plots. RESULTS: The geometric mean concentrations (detection rates) were 0.09 ng/mL (100.0%), 0.12 ng/mL (97.8%), 0.22 ng/mL (94.7%), 0.16 ng/mL (99.2%) and 0.28 ng/mL (100.0%) for PBDE-28, PBDE-47, PBDE-99, and PBDE-153 respectively. However, PBDE-28, PBDE-99, PBDE-100, and SigmaPBDEs were positively associated with IFG (odds ratios (ORs) (95% confidence intervals (CIs)): 1.14 (1.06, 1.23), 1.16 (1.04, 1.29), 1.25 (1.14, 1.37), and 1.27 (1.08, 1.50)). Similarly, PBDE-28, PBDE-47, PBDE-99, PBDE-100, and SigmaPBDEs were positively associated with T2DM (ORs (95% CIs): 1.30 (1.10, 1.54), 1.13 (1.06, 1.22), 1.27 (1.13, 1.43), 1.27 (1.15, 1.40), and 1.30 (1.10, 1.54)). Moreover, five PBDE mixtures or jointly as PBDE pollution score, were significantly associated with an increased risk of T2DM (P < 0.05 for all). In addition, the harmful effect of PBDE exposure on T2DM was decreased with accompanying high-density lipoprotein cholesterol (HDL-C) levels increased. CONCLUSIONS: Our findings highlight the importance of managing PBDEs contamination and suggest that HDL-C may be a novel way to prevent T2DM. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Xu, Qingqing AU - Xu Q AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Fan, Keliang AU - Fan K AD - Teaching and Training Department, Affiliated Hospital of Jiaxing University/ The First Hospital of Jiaxing, 314000 Zhejiang, China. FAU - Wei, Dandan AU - Wei D AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Lulu AU - Wang L AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Juan AU - Wang J AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Song, Yu AU - Song Y AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Mian AU - Wang M AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Zhao, Mengzhen AU - Zhao M AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Liu, Xiaotian AU - Liu X AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Huo, Wenqian AU - Huo W AD - Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Li, Linlin AU - Li L AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Hou, Jian AU - Hou J AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Jing, Tao AU - Jing T AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Wang, Chongjian AU - Wang C AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Mao, Zhenxing AU - Mao Z AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: maozhr@gmail.com. LA - eng PT - Journal Article DEP - 20230928 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 SB - IM OTO - NOTNLM OT - High-density lipoprotein cholesterol OT - Impaired fasting glucose OT - Polybrominated diphenyl ethers OT - Type 2 diabetes mellitus COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/01 04:44 MHDA- 2023/10/01 04:44 CRDT- 2023/09/30 18:13 PHST- 2023/01/27 00:00 [received] PHST- 2023/09/21 00:00 [revised] PHST- 2023/09/24 00:00 [accepted] PHST- 2023/10/01 04:44 [pubmed] PHST- 2023/10/01 04:44 [medline] PHST- 2023/09/30 18:13 [entrez] AID - S0147-6513(23)01028-X [pii] AID - 10.1016/j.ecoenv.2023.115524 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2023 Oct 15;265:115524. doi: 10.1016/j.ecoenv.2023.115524. Epub 2023 Sep 28.