PMID- 37777136
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231115
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 906
DP  - 2024 Jan 1
TI  - Associations of exposure to metals with total and allergen-specific IgE: An 
      NHANES analysis (2005-2006).
PG  - 167385
LID - S0048-9697(23)06012-6 [pii]
LID - 10.1016/j.scitotenv.2023.167385 [doi]
AB  - BACKGROUND: Immunoglobulin E (IgE) is a diagnostic biomarker for allergic 
      diseases. While some metal exposure has been found to be associated with allergic 
      diseases, there are still a lot of knowledge gaps regarding the relationship 
      between metal exposure and allergen-specific IgE antibodies, particularly in 
      adults. METHODS: We included a total of 1433 adult participants from the 
      2005-2006 National Health and Nutrition Examination Survey (NHANES), all of whom 
      had concentrations of 10 metals (including Barium (Ba), Cadmium (Cd), Cobalt 
      (Co), Cesium (Cs), Molybdenum (Mo), Lead (Pb), Antimony (Sb), Thallium (Tl), 
      Tungsten (Tu), and Uranium (Ur)) in urine, as well as measurements of 19 
      allergen-specific IgE and total IgE antibodies. Linear regression, logistic 
      regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine 
      regression (BKMR) were used to estimate associations between metals and total and 
      allergen-specific IgE. RESULTS: Linear regression models revealed a positive 
      correlation between Pb and Cd levels and the total IgE levels. Furthermore, the 
      WQS and BKMR models suggested a positive association between mixed metals and 
      total IgE levels, with the WQS model highlighting Pb and Cd as the major 
      contributors. Logistic regression models showed positive correlations between Pb 
      and food sensitization, Ur and plant sensitization, negative correlations between 
      Cs and plant sensitization, Co and dust mite and pet sensitization, Mo and dust 
      mite and cockroach sensitization, and Tl and mold sensitization. Moreover, the 
      BKMR results indicated a statistically significant negative correlation between 
      mixed metals and mold sensitization. CONCLUSION: According to the research 
      findings, exposure to metals is associated with total and allergen-specific IgE 
      in American adults. Further assessment of these relationships is necessary in 
      representative populations of other countries.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Ran, Zhujie
AU  - Ran Z
AD  - Department of Preventive Medicine, School of Public Health and Management, 
      Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
FAU - Wang, Ben
AU  - Wang B
AD  - Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100730, China.
FAU - Zhang, Shu-Yun
AU  - Zhang SY
AD  - Department of Preventive Medicine, School of Public Health and Management, 
      Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; School of Medicine, 
      Taizhou University, Taizhou, Zhejiang 318000, China. Electronic address: 
      shuyunzh@wmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230928
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - 0 (Allergens)
RN  - 3G0H8C9362 (Cobalt)
RN  - 81AH48963U (Molybdenum)
RN  - AD84R52XLF (Thallium)
RN  - 1KSV9V4Y4I (Cesium)
RN  - 4OC371KSTK (Uranium)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Nutrition Surveys
MH  - Cadmium
MH  - Bayes Theorem
MH  - Lead
MH  - Allergens
MH  - *Hypersensitivity
MH  - Cobalt
MH  - Molybdenum
MH  - Thallium
MH  - Fungi
MH  - Cesium
MH  - *Uranium
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Allergic sensitization
OT  - Antibodies
OT  - Bayesian kernel machine regression (BKMR)
OT  - Metals
OT  - Weighted quantile sum (WQS) regression
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/01 04:44
MHDA- 2023/11/15 06:43
CRDT- 2023/09/30 19:17
PHST- 2023/05/14 00:00 [received]
PHST- 2023/08/03 00:00 [revised]
PHST- 2023/09/24 00:00 [accepted]
PHST- 2023/11/15 06:43 [medline]
PHST- 2023/10/01 04:44 [pubmed]
PHST- 2023/09/30 19:17 [entrez]
AID - S0048-9697(23)06012-6 [pii]
AID - 10.1016/j.scitotenv.2023.167385 [doi]
PST - ppublish
SO  - Sci Total Environ. 2024 Jan 1;906:167385. doi: 10.1016/j.scitotenv.2023.167385. 
      Epub 2023 Sep 28.