PMID- 37778111
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 45
IP  - 1
DP  - 2024 Jan-Feb
TI  - The impact of menopausal status on auditory brainstem responses.
PG  - 104067
LID - S0196-0709(23)00281-8 [pii]
LID - 10.1016/j.amjoto.2023.104067 [doi]
AB  - OBJECTIVE: To determine the effect of decreased estrogen levels due to menopause 
      on auditory brainstem response measurements (ABR). STUDY DESIGN: Retrospective 
      chart review. SETTING: Academic. PATIENTS: Pre- and post-menopausal females 
      (pre-M, post-M) and age-matched males. METHODS: ABR measurements of wave I, III, 
      and V latencies, and interpeak latencies; amplitudes of waves I, III, V, and V/I 
      ratio. OUTCOME MEASURE: Differences in ABR measurements between pre-M and post-M. 
      RESULTS: 164 subjects (101 female and 64 male) were included. Post-M had 
      significantly greater latencies (msec) than pre-M of wave V. Post-M had a 
      significantly smaller wave I amplitude (uV) than pre-M. Post-M had a 
      significantly higher wave V/I amplitude ratio than pre-M. Pre-M had significantly 
      shorter latencies than young males for wave III, and wave V. Post-M had 
      significantly shorter latencies than older males at wave III, and wave V. A 
      two-way ANOVA revealed a significant interaction between the effects of age 
      category and gender on V/I amplitude. CONCLUSION: Post-M group showed a 
      significant drop in wave I amplitude compared with pre-M group, even in the 
      absence of hearing loss, suggesting that the gender differences in hearing are 
      related to estrogen signaling along the auditory pathway. If wave I amplitude 
      changes between older and younger groups resulted from decreased peripheral 
      hearing sensitivity, we would expect larger drops in amplitude in males since 
      rates of presbycusis are higher. We observed much larger drops in wave I 
      amplitude in females, which cannot be attributed to peripheral hearing loss. 
      These results may assist in understanding gender differences in presbycusis and a 
      possible protective effect of estrogen on the auditory system. Knowledge of 
      gender differences in wave I may be important when ABR is used to assess possible 
      synaptopathy.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Yam, Christopher
AU  - Yam C
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, PA, United States of America. Electronic address: 
      Cwy25@drexel.edu.
FAU - McGovern, Brian
AU  - McGovern B
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, PA, United States of America. Electronic address: 
      brian.m.mcgovern@gmail.com.
FAU - Boyajieff, Emma
AU  - Boyajieff E
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, PA, United States of America. Electronic address: 
      egb47@drexel.edu.
FAU - Maxwell, Philip
AU  - Maxwell P
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, PA, United States of America. Electronic address: 
      pjm365@drexel.edu.
FAU - Little, Kara
AU  - Little K
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, PA, United States of America. Electronic address: 
      klittle@phillyent.com.
FAU - Sataloff, Robert T
AU  - Sataloff RT
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, PA, United States of America; Senior Associate Dean for 
      Clinical Academic Specialties, Drexel University College of Medicine, United 
      States of America. Electronic address: rtsataloff@phillyent.com.
LA  - eng
PT  - Journal Article
DEP - 20230928
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Estrogens)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Presbycusis
MH  - Retrospective Studies
MH  - Evoked Potentials, Auditory, Brain Stem
MH  - *Deafness
MH  - Menopause
MH  - Estrogens
MH  - Auditory Threshold/physiology
OTO - NOTNLM
OT  - Auditory brainstem response
OT  - Estrogen
OT  - Menopause
COIS- Declaration of competing interest None.
EDAT- 2023/10/02 00:41
MHDA- 2023/12/17 09:44
CRDT- 2023/10/01 18:03
PHST- 2023/07/15 00:00 [received]
PHST- 2023/09/21 00:00 [revised]
PHST- 2023/09/24 00:00 [accepted]
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/10/02 00:41 [pubmed]
PHST- 2023/10/01 18:03 [entrez]
AID - S0196-0709(23)00281-8 [pii]
AID - 10.1016/j.amjoto.2023.104067 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2024 Jan-Feb;45(1):104067. doi: 10.1016/j.amjoto.2023.104067. 
      Epub 2023 Sep 28.