PMID- 37779106
OWN - NLM
STAT- Publisher
LR  - 20240201
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 21
IP  - 2
DP  - 2023 Oct 1
TI  - Effect of Piascledine-bacterial nanocellulose combination on experimental 
      cutaneous wound healing in rat: Histopathological, biochemical and molecular 
      studies.
LID - 10.1111/iwj.14418 [doi]
LID - e14418
AB  - The study investigated the wound healing potential of Piascledine (an 
      avocado/soybean mixture) alone and in combination with bacterial nanocellulose on 
      rat cutaneous wounds. Full-thickness excisional wounds (2 cm in diameter) were 
      induced on the backs of 60 Sprague-Dawley rats, divided into four groups, treated 
      with daily topical application of bacterial nanocellulose (BNC), Piascledine 10% 
      (PSD 10%) and Piascledine+bacterial nanocellulose (PSD + BNC) (10 mg/disk) and 
      normal saline (control) for 20 days. Wounds were monitored daily, and at 10, 20 
      and 30 days post-injury (DPI), tissue samples were collected for biochemical, 
      histopathological and molecular analyses. Treated rats with PSD and PSD + BNC 
      showed a significant decrease in the wound area compared with other groups. PSD 
      and particularly PSD + BNC modulated inflammation, improved fibroplasia and 
      angiogenesis and scar tissue formation at short term. At the long term, they 
      reduced the scar tissue size and improved collagen fibres alignment, tissue 
      organization and remodelling as well as re-epithelialization. PSD enhanced matrix 
      metalloproteinase-3 (MMP-3) gene expression, collagen and glycosaminoglycans 
      (GAGs) synthesis and decreased tissue inhibitor of metalloproteinase-1 (TIMP-1) 
      gene expression at various stages of wound healing. The study concluded that 
      topical application of Piascledine, particularly in combination with bacterial 
      nanocellulose, promotes wound healing activity by modulating inflammation, 
      regulating MMP-3 expression and enhancing collagen and GAGs synthesis.
CI  - (c) 2023 The Authors. International Wound Journal published by Medicalhelplines.com 
      Inc and John Wiley & Sons Ltd.
FAU - Panahi, Nastaran
AU  - Panahi N
AD  - Department of Pathobiology, Veterinary Medicine Faculty, Razi University, 
      Kermanshah, Iran.
FAU - Hashemnia, Mohammad
AU  - Hashemnia M
AD  - Department of Pathobiology, Veterinary Medicine Faculty, Razi University, 
      Kermanshah, Iran.
FAU - Rezaei, Farid
AU  - Rezaei F
AD  - Department of Pathobiology, Veterinary Medicine Faculty, Razi University, 
      Kermanshah, Iran.
FAU - Cheraghi, Hadi
AU  - Cheraghi H
AD  - Department of Clinical Sciences, Veterinary Medicine Faculty, Razi University, 
      Kermanshah, Iran.
LA  - eng
PT  - Journal Article
DEP - 20231001
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
SB  - IM
PMC - PMC10825074
OTO - NOTNLM
OT  - MMP-3
OT  - Piascledine
OT  - TIMP-1
OT  - bacterial nanocellulose
OT  - histopathology
OT  - skin wound
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2023/10/02 00:41
MHDA- 2023/10/02 00:41
PMCR- 2023/10/01
CRDT- 2023/10/01 22:52
PHST- 2023/09/15 00:00 [revised]
PHST- 2023/08/07 00:00 [received]
PHST- 2023/09/16 00:00 [accepted]
PHST- 2023/10/02 00:41 [medline]
PHST- 2023/10/02 00:41 [pubmed]
PHST- 2023/10/01 22:52 [entrez]
PHST- 2023/10/01 00:00 [pmc-release]
AID - IWJ14418 [pii]
AID - 10.1111/iwj.14418 [doi]
PST - aheadofprint
SO  - Int Wound J. 2023 Oct 1;21(2):e14418. doi: 10.1111/iwj.14418.