PMID- 37779113
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240312
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Linking)
VI  - 63
IP  - 1
DP  - 2024 Feb
TI  - Associations of dietary advanced glycation end products with liver steatosis via 
      vibration controlled transient elastography in the United States: a nationwide 
      cross-sectional study.
PG  - 173-183
LID - 10.1007/s00394-023-03253-2 [doi]
AB  - PURPOSE: Large population-based studies for the associations between dietary 
      advanced glycation end products (dAGEs) intake and liver steatosis remain 
      lacking. It is necessary to clarify the relationship of dAGEsintake with liver 
      steatosis through the National Health and Nutrition Survey (NHANES). METHODS: A 
      total of 5856 participants in the NHANES 2017-2018 were included. The dietary 
      AGEs intake, including epsilon-(carboxymethyl)lysine(CML), Nepsilon-(1-carboxyethyl)lysine 
      (CEL), and Ndelta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were 
      estimated using the combination of ultra-performance LC-tandem MS dietary AGEs 
      database and two 24-h dietary recall interviews. Liver steatosis was assessed by 
      controlled attenuation parameter via transient elastography. Logistic regression 
      model was adopted to explore the relationships between dAGEs intake and hepatic 
      steatosis. RESULTS: Compared with individuals of total dAGEs, CML, MG-H1 in the 
      lowest tertile, those in the highest tertile had highest risk of hepatic 
      steatosis, and the corresponding odds radios(ORs) (95% confidence interval(CI)) 
      were 1.37 (1.01, 1.84), 1.36 (1.04,1.78) and 1.40 (1.06, 1.85), respectively. 
      Subgroups analysis found that the positive association between dAGEs, CML, CEL 
      and MG-H1 and hepatic steatosis appeared stronger in subjects with obesity and 
      those with abnormal waist circumference (WC). CONCLUSION: There was a positive 
      correlation between dAGEs, CML, MG-H1, and hepatic steatosis, and this 
      association mainly existed in subjects with obesity and those with abnormal WC. 
      Dietary AGEs restriction might be of high priority for subjects with obesity for 
      the prevention of fatty liver disease. Further longitudinal studies are required 
      to confirm the causal associations and explore the potential mechanisms.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Xie, Fangfei
AU  - Xie F
AD  - Physical Examination Center, Gusu School, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical 
      University, 242 Guangji Road, Suzhou, 215008, China.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Physical Examination Center, Gusu School, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical 
      University, 242 Guangji Road, Suzhou, 215008, China.
FAU - Liu, Di
AU  - Liu D
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, 199 Ren'ai Road, Suzhou, 215123, China.
FAU - Wan, Zhongxiao
AU  - Wan Z
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, 199 Ren'ai Road, Suzhou, 215123, China.
FAU - Sun, Kangyun
AU  - Sun K
AD  - Physical Examination Center, Gusu School, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical 
      University, 242 Guangji Road, Suzhou, 215008, China. sunkangyun2023tj@126.com.
FAU - Wang, Yun
AU  - Wang Y
AD  - Physical Examination Center, Gusu School, The Affiliated Suzhou Hospital of 
      Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical 
      University, 242 Guangji Road, Suzhou, 215008, China. 714388761@qq.com.
LA  - eng
GR  - 82073535/National Natural Science Foundation of China/
GR  - LKM2023037/Jiangsu Commission of Health/
PT  - Journal Article
DEP - 20231002
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Dietary Advanced Glycation End Products)
RN  - 0 (Glycation End Products, Advanced)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Humans
MH  - United States/epidemiology
MH  - Dietary Advanced Glycation End Products
MH  - Glycation End Products, Advanced
MH  - Cross-Sectional Studies
MH  - *Elasticity Imaging Techniques
MH  - Lysine
MH  - Vibration
MH  - Nutrition Surveys
MH  - *Non-alcoholic Fatty Liver Disease/diagnostic imaging/epidemiology
MH  - Obesity
OTO - NOTNLM
OT  - Dietary advanced glycation end products
OT  - Liver steatosis
OT  - National Health and Nutrition Survey
EDAT- 2023/10/02 00:41
MHDA- 2024/01/22 06:42
CRDT- 2023/10/01 23:06
PHST- 2023/05/12 00:00 [received]
PHST- 2023/09/08 00:00 [accepted]
PHST- 2024/01/22 06:42 [medline]
PHST- 2023/10/02 00:41 [pubmed]
PHST- 2023/10/01 23:06 [entrez]
AID - 10.1007/s00394-023-03253-2 [pii]
AID - 10.1007/s00394-023-03253-2 [doi]
PST - ppublish
SO  - Eur J Nutr. 2024 Feb;63(1):173-183. doi: 10.1007/s00394-023-03253-2. Epub 2023 
      Oct 2.