PMID- 37779520
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 2772-8293 (Electronic)
IS  - 2772-8293 (Linking)
VI  - 2
IP  - 3
DP  - 2023 Aug
TI  - Associations between HLA class II alleles and IgE sensitization to allergens in 
      the Qatar Biobank cohort.
PG  - 100117
LID - 10.1016/j.jacig.2023.100117 [doi]
LID - 100117
AB  - BACKGROUND: Allergic disorders are the consequence of IgE sensitization to 
      allergens. Population studies have shown that certain human leukocyte antigen 
      (HLA) alleles are associated with increased or decreased risk of developing 
      allergy. OBJECTIVE: We aimed to characterize the relationship between HLA class 
      II allelic diversity and IgE sensitization in an understudied Arab population. 
      METHODS: We explored associations between IgE sensitization to 7 allergen mixes 
      and mesquite (comprising 41 food or aeroallergens) and 45 common classical HLA 
      class II alleles in a well-defined cohort of 797 individuals representing the 
      general adult population of Qatari nationals and long-term residents. To do so, 
      we performed HLA calling from whole genome sequencing data at 2-field resolution 
      using 2 independent algorithms. We then applied 3 different regression models to 
      assess either each allergen mix independently, in the context of IgE 
      sensitization to other allergens tested, or polysensitization. RESULTS: More than 
      half (n = 447) of the study participants showed IgE sensitization to at least 1 
      allergen, most of them (n = 400) to aeroallergens (Phadiatop). We identified 
      statistically significant negative and positive associations with 24 HLA class II 
      alleles. These have been reported to confer risk or protection from variety of 
      diseases; however, only a few have previously been associated with allergy in 
      other populations. CONCLUSIONS: Our study reveals several new risk and protective 
      genetic markers for allergen-specific IgE sensitization. This is a first and 
      essential step toward a better understanding of the origins of allergic diseases 
      in this understudied population.
CI  - (c) 2023 The Author(s).
FAU - Khan, Taushif
AU  - Khan T
AD  - Department of Human Immunology, Sidra Medicine, Doha, Qatar.
AD  - Department of Computational Science, The Jackson Laboratory, Farmington, Conn.
FAU - Ledoux, Isabella Marie
AU  - Ledoux IM
AD  - the Department of Pathology, Sidra Medicine, Doha, Qatar.
FAU - Aziz, Ferdousey
AU  - Aziz F
AD  - the Department of Pathology, Sidra Medicine, Doha, Qatar.
FAU - Al Ali, Fatima
AU  - Al Ali F
AD  - Department of Human Immunology, Sidra Medicine, Doha, Qatar.
FAU - Chin-Smith, Evonne
AU  - Chin-Smith E
AD  - Department of Human Immunology, Sidra Medicine, Doha, Qatar.
FAU - Ata, Manar
AU  - Ata M
AD  - Department of Human Immunology, Sidra Medicine, Doha, Qatar.
FAU - Karim, Mohammed Yousuf
AU  - Karim MY
AD  - the Department of Pathology, Sidra Medicine, Doha, Qatar.
AD  - the College of Medicine, Qatar University, Doha, Qatar.
FAU - Marr, Nico
AU  - Marr N
AD  - Department of Human Immunology, Sidra Medicine, Doha, Qatar.
AD  - the College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, 
      Qatar.
AD  - Institute of Translational Immunology, Brandenburg Medical School, Brandenburg an 
      der Havel, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230518
PL  - United States
TA  - J Allergy Clin Immunol Glob
JT  - The journal of allergy and clinical immunology. Global
JID - 9918453488706676
PMC - PMC10509938
OTO - NOTNLM
OT  - Allergens
OT  - IgE sensitization
OT  - Qatar Biobank
OT  - association study
EDAT- 2023/10/02 06:42
MHDA- 2023/10/02 06:43
PMCR- 2023/05/18
CRDT- 2023/10/02 04:14
PHST- 2022/07/06 00:00 [received]
PHST- 2023/01/16 00:00 [revised]
PHST- 2023/02/05 00:00 [accepted]
PHST- 2023/10/02 06:43 [medline]
PHST- 2023/10/02 06:42 [pubmed]
PHST- 2023/10/02 04:14 [entrez]
PHST- 2023/05/18 00:00 [pmc-release]
AID - S2772-8293(23)00042-5 [pii]
AID - 100117 [pii]
AID - 10.1016/j.jacig.2023.100117 [doi]
PST - epublish
SO  - J Allergy Clin Immunol Glob. 2023 May 18;2(3):100117. doi: 
      10.1016/j.jacig.2023.100117. eCollection 2023 Aug.