PMID- 37780548
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231003
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Print)
IS  - 1792-1074 (Linking)
VI  - 26
IP  - 5
DP  - 2023 Nov
TI  - High hsa_circ_0081621 expression indicates a poor prognosis of laryngeal squamous 
      cell carcinoma: A bioinformatics analysis and retrospective clinical study.
PG  - 464
LID - 10.3892/ol.2023.14051 [doi]
LID - 464
AB  - Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant 
      tumour of the head and neck with a low 5-year survival rate. There is need to 
      identify novel biomarkers for diagnosis and treatment of LSCC. The present study 
      identified differentially expressed circular RNAs (circRNAs/circs) in LSCC and 
      larynx adjacent non-carcinoma epithelial specimens by analysing the circRNA 
      microarray dataset GSE117001. hsa_circ_0081621 had highest expression among three 
      circRNAs (hsa_circ_0015211, hsa_circ_0023326 and hsa_circ_0081621) in LSCC 
      specimens by reverse transcription-quantitative PCR. The expression levels of 
      hsa_circ_0081621 in 67 LSCC specimens were detected by fluorescence in situ 
      hybridization (FISH). Expression levels of hsa_circ_0081621 were analysed in 
      relation to clinicopathological parameters and prognosis of patients with LSCC. 
      According to FISH results, 59.7% of LSCC specimens exhibited high 
      hsa_circ_0081621 expression. In LSCC specimens, hsa_circ_0081621 high expression 
      was associated with lymph node metastasis and high clinical stage. High 
      expression levels of hsa_circ_0081621 were associated with a poor 5-year overall 
      survival rate in patients with LSCC. In addition, high hsa_circ_0081621 
      expression was an independent prognostic factor for patients with LSCC. 
      hsa_circ_0081621 may participate in malignant progression of LSCC, and its high 
      expression could be used for prognostic assessment of patients with LSCC.
CI  - Copyright: (c) Liu et al.
FAU - Liu, Meng
AU  - Liu M
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Fourth Hospital of 
      Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
FAU - Zhao, Ruili
AU  - Zhao R
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Fourth Hospital of 
      Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
FAU - Song, Xiaofei
AU  - Song X
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Fourth Hospital of 
      Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
FAU - Cheng, Hongkun
AU  - Cheng H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Third Hospital of 
      Handan City, Handan, Hebei 056001, P.R. China.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Fourth Hospital of 
      Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
FAU - Xu, Yuru
AU  - Xu Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Fourth Hospital of 
      Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
FAU - Liu, Shenghui
AU  - Liu S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Fourth Hospital of 
      Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20230914
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC10534280
OTO - NOTNLM
OT  - circular RNA
OT  - hsa_circ_0081621
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
COIS- The authors declare that they have no competing interests.
EDAT- 2023/10/02 06:42
MHDA- 2023/10/02 06:43
PMCR- 2023/09/14
CRDT- 2023/10/02 04:29
PHST- 2023/05/29 00:00 [received]
PHST- 2023/08/23 00:00 [accepted]
PHST- 2023/10/02 06:43 [medline]
PHST- 2023/10/02 06:42 [pubmed]
PHST- 2023/10/02 04:29 [entrez]
PHST- 2023/09/14 00:00 [pmc-release]
AID - OL-26-5-14051 [pii]
AID - 10.3892/ol.2023.14051 [doi]
PST - epublish
SO  - Oncol Lett. 2023 Sep 14;26(5):464. doi: 10.3892/ol.2023.14051. eCollection 2023 
      Nov.