PMID- 37780620
OWN - NLM
STAT- MEDLINE
DCOM- 20231101
LR  - 20231101
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Effects of hypertension on subcortical nucleus morphological alternations in 
      patients with type 2 diabetes.
PG  - 1201281
LID - 10.3389/fendo.2023.1201281 [doi]
LID - 1201281
AB  - OBJECTIVES: Type 2 diabetes mellitus(T2DM) and hypertension(HTN) are common 
      comorbidities, and known to affect the brain. However, little is known about the 
      effects of the coexisting HTN on brain in T2DM patients. So we aim to investigate 
      the impact of HTN on the subcortical nucleus morphological alternations in T2DM 
      patients. MATERIALS & METHODS: This work was registered by the clinicaltrials.gov 
      (grant number NCT03564431). We recruited a total of 92 participants, comprising 
      36 only T2DM patients, 28 T2DM patients with HTN(T2DMH) and 28 healthy 
      controls(HCs) in our study. All clinical indicators were assessed and brain image 
      data was collected for each participant. Voxel-based morphometry(VBM), automatic 
      volume and vertex-based shape analyses were used to determine the subcortical 
      nucleus alternations from each participant's 3D-T1 brain images and evaluate the 
      relationship between the alternations and clinical indicators. RESULTS: T2DMH 
      patients exhibited volumetric reduction and morphological alterations in thalamus 
      compared to T2DM patients, whereas T2DM patients did not demonstrate any 
      significant subcortical alterations compared to HCs. Furthermore, negative 
      correlations have been found between thalamic alternations and the duration of 
      HTN in T2DMH patients. CONCLUSION: Our results revealed that HTN may exacerbate 
      subcortical nucleus alternations in T2DM patients, which highlighted the 
      importance of HTN management in T2DM patients to prevent further damage to the 
      brain health.
CI  - Copyright (c) 2023 Cui, Ouyang, Zeng, Ling, Shi, Zhu, Gu, Jiang, Zhou, Sun, Han and 
      Lu.
FAU - Cui, Feng
AU  - Cui F
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Ouyang, Zhi-Qiang
AU  - Ouyang ZQ
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Zeng, Yi-Zhen
AU  - Zeng YZ
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Ling, Bing-Bing
AU  - Ling BB
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Shi, Li
AU  - Shi L
AD  - Department of Endocrinology, First Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan, China.
FAU - Zhu, Yun
AU  - Zhu Y
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Gu, He-Yi
AU  - Gu HY
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Jiang, Wan-Lin
AU  - Jiang WL
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Zhou, Ting
AU  - Zhou T
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Sun, Xue-Jin
AU  - Sun XJ
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Han, Dan
AU  - Han D
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Lu, Yi
AU  - Lu Y
AD  - Department of Medical Imaging, Laboratory of Brain Function, First Affiliated 
      Hospital of Kunming Medical University, Kunming, Yunnan, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT03564431
PT  - Clinical Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230913
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - Brain
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Head
MH  - *Hypertension/complications
MH  - Imaging, Three-Dimensional
PMC - PMC10534025
OTO - NOTNLM
OT  - hypertension
OT  - shape analysis
OT  - subcortical nucleus
OT  - type 2 diabetes mellitus
OT  - volume analysis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/02 06:42
MHDA- 2023/10/31 06:42
PMCR- 2023/01/01
CRDT- 2023/10/02 04:31
PHST- 2023/04/06 00:00 [received]
PHST- 2023/08/28 00:00 [accepted]
PHST- 2023/10/31 06:42 [medline]
PHST- 2023/10/02 06:42 [pubmed]
PHST- 2023/10/02 04:31 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1201281 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Sep 13;14:1201281. doi: 
      10.3389/fendo.2023.1201281. eCollection 2023.