PMID- 37783783
OWN - NLM
STAT- MEDLINE
DCOM- 20240131
LR  - 20240206
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Linking)
VI  - 25
IP  - 2
DP  - 2024 Feb
TI  - Mechanisms controlling cellular and systemic iron homeostasis.
PG  - 133-155
LID - 10.1038/s41580-023-00648-1 [doi]
AB  - In mammals, hundreds of proteins use iron in a multitude of cellular functions, 
      including vital processes such as mitochondrial respiration, gene regulation and 
      DNA synthesis or repair. Highly orchestrated regulatory systems control cellular 
      and systemic iron fluxes ensuring sufficient iron delivery to target proteins is 
      maintained, while limiting its potentially deleterious effects in iron-mediated 
      oxidative cell damage and ferroptosis. In this Review, we discuss how cells 
      acquire, traffick and export iron and how stored iron is mobilized for 
      iron-sulfur cluster and haem biogenesis. Furthermore, we describe how these 
      cellular processes are fine-tuned by the combination of various sensory and 
      regulatory systems, such as the iron-regulatory protein (IRP)-iron-responsive 
      element (IRE) network, the nuclear receptor co-activator 4 (NCOA4)-mediated 
      ferritinophagy pathway, the prolyl hydroxylase domain (PHD)-hypoxia-inducible 
      factor (HIF) axis or the nuclear factor erythroid 2-related factor 2 (NRF2) 
      regulatory hub. We further describe how these pathways interact with systemic 
      iron homeostasis control through the hepcidin-ferroportin axis to ensure 
      appropriate iron fluxes. This knowledge is key for the identification of novel 
      therapeutic opportunities to prevent diseases of cellular and/or systemic iron 
      mismanagement.
CI  - (c) 2023. Springer Nature Limited.
FAU - Galy, Bruno
AU  - Galy B
AUID- ORCID: 0000-0002-0501-6357
AD  - German Cancer Research Center (DKFZ), Division of Virus-associated Carcinogenesis 
      (F170), Heidelberg, Germany.
FAU - Conrad, Marcus
AU  - Conrad M
AUID- ORCID: 0000-0003-1140-5612
AD  - Helmholtz Zentrum Munchen, Institute of Metabolism and Cell Death, Neuherberg, 
      Germany.
FAU - Muckenthaler, Martina
AU  - Muckenthaler M
AUID- ORCID: 0000-0002-3778-510X
AD  - Department of Paediatric Hematology, Oncology and Immunology, University of 
      Heidelberg, Heidelberg, Germany. Martina.Muckenthaler@med.uni-heidelberg.de.
AD  - Molecular Medicine Partnership Unit, University of Heidelberg, Heidelberg, 
      Germany. Martina.Muckenthaler@med.uni-heidelberg.de.
AD  - German Centre for Cardiovascular Research (DZHK), Partner site 
      Heidelberg/Mannheim, Heidelberg, Germany. 
      Martina.Muckenthaler@med.uni-heidelberg.de.
AD  - Translational Lung Research Center Heidelberg (TLRC), German Center for Lung 
      Research (DZL), University of Heidelberg, Heidelberg, Germany. 
      Martina.Muckenthaler@med.uni-heidelberg.de.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231002
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - E1UOL152H7 (Iron)
RN  - 0 (Iron-Regulatory Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Iron/metabolism
MH  - Iron-Regulatory Proteins/genetics/metabolism
MH  - *Transcription Factors/metabolism
MH  - Homeostasis/physiology
MH  - Oxidative Stress
MH  - Mammals/metabolism
EDAT- 2023/10/03 00:42
MHDA- 2024/01/31 06:42
CRDT- 2023/10/02 23:27
PHST- 2023/07/31 00:00 [accepted]
PHST- 2024/01/31 06:42 [medline]
PHST- 2023/10/03 00:42 [pubmed]
PHST- 2023/10/02 23:27 [entrez]
AID - 10.1038/s41580-023-00648-1 [pii]
AID - 10.1038/s41580-023-00648-1 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2024 Feb;25(2):133-155. doi: 10.1038/s41580-023-00648-1. 
      Epub 2023 Oct 2.