PMID- 3778580 OWN - NLM STAT- MEDLINE DCOM- 19870122 LR - 20041117 IS - 0883-1386 (Print) IS - 0883-1386 (Linking) VI - 7 IP - 2 DP - 1987 TI - Heavy drinking decreases plasma met-enkephalin concentrations. PG - 93-8 AB - Plasma met-enkephalin immunoreactive material (ME-IR) concentration was measured in 175 aged subjects (68 males, 107 females). Heavy drinking (1 liter of red or white wine a day, equivalent roughly to greater than 110 g ethanol) was associated with reduced ME-IR concentrations. On the other hand, no correlation was found between plasma ME-IR and other parameters such as blood pressure, age or body weight. These data favor the hypothesis of an involvement of ME-IR in the mechanisms of ethanol action. FAU - Govoni, S AU - Govoni S FAU - Pasinetti, G AU - Pasinetti G FAU - Bianchi, A AU - Bianchi A FAU - Gadola, M AU - Gadola M FAU - Trabucchi, M AU - Trabucchi M LA - eng PT - Journal Article PL - United States TA - Alcohol Drug Res JT - Alcohol and drug research JID - 8601074 RN - 58569-55-4 (Enkephalin, Methionine) SB - IM MH - Aged MH - Alcoholism/*blood MH - Depression, Chemical MH - Enkephalin, Methionine/*blood MH - Female MH - Humans MH - Male MH - Middle Aged MH - Sex Factors EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] PST - ppublish SO - Alcohol Drug Res. 1987;7(2):93-8.