PMID- 37787034
OWN - NLM
STAT- MEDLINE
DCOM- 20240321
LR  - 20240321
IS  - 1897-5631 (Electronic)
IS  - 0239-8508 (Linking)
VI  - 61
IP  - 3
DP  - 2023
TI  - Expression of CD105 but not of E-cadherin is associated with malignancy 
      recurrence and disease-free interval in laryngeal cancer in men.
PG  - 183-192
LID - 10.5603/fhc.97035 [doi]
AB  - INTRODUCTION: In this study we analyzed CD105 (endoglin) and E-cadherin 
      expression in laryngeal squamous cell carcinoma (LSCC) to evaluate their 
      clinicopathologic significance. MATERIAL AND METHODS: Expression of CD105 and 
      E-cadherin was examined immunohistochemically using paraffin-embedded archival 
      tissues of 72 (35 glottic and 37 supraglottic) previously untreated LSCC male 
      patients. The mean value of the positively-stained microvessels for CD105 counted 
      in four hot spots for each case was used as the final intratumoralmicrovessel 
      density (MVD). A staining score of E-cadherin was calculated based on the 
      percentage of cells stained (0-100%). RESULTS: MVD was significantly higher in 
      patients with advanced TNM stage (P = 0.004) and younger than 65 (P = 0.008). 
      Nodal metastases were more frequent in the cases with low E-cadherin expression 
      (P = 0.000). Tumor recurrence was associated with advanced TNM stage (P = 0.035) 
      and high MVD (P = 0.002). A high MVD was an independent predictor of malignancy 
      recurrence (P = 0.021). The log-rank test showed a significant difference in the 
      disease-free interval in patients stratified according to the MVD value (P = 
      0.016). Spearman's rank correlation test did not show a significant correlation 
      between E-cadherin and CD105 expression. CONCLUSIONS: CD105-assessed MVD and 
      expression of E-cadherin are promising prognostic factors for the outcome of 
      patients with LSCC. Increased expression of CD105 could help predict patients 
      with an increased risk of developing loco-regional recurrence after surgical 
      treatment. Decreased E-cadherin expression is a potential predictor of lymph node 
      metastases.
FAU - Zvrko, Elvir
AU  - Zvrko E
AUID- ORCID: 0000-0002-8561-0849
AD  - Clinic of Otorhinolaryngology, Clinical Center of Montenegro, Podgorica, 
      Montenegro. elvir@zvrko.me.
AD  - Faculty of Medicine, University of Montenegro, Podgorica, Montenegro. 
      elvir@zvrko.me.
FAU - Vuckovic, Ljiljana
AU  - Vuckovic L
AD  - Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
AD  - Center of Pathology, Clinical Center of Montenegro, Podgorica, Montenegro.
LA  - eng
PT  - Journal Article
DEP - 20231003
PL  - Poland
TA  - Folia Histochem Cytobiol
JT  - Folia histochemica et cytobiologica
JID - 8502651
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cadherins)
RN  - 0 (Endoglin)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (ENG protein, human)
RN  - 0 (CDH1 protein, human)
SB  - IM
MH  - Humans
MH  - Male
MH  - Biomarkers, Tumor/metabolism
MH  - Cadherins
MH  - *Carcinoma, Squamous Cell
MH  - Endoglin
MH  - *Laryngeal Neoplasms/diagnosis/metabolism/pathology
MH  - Neovascularization, Pathologic/metabolism/pathology
MH  - Receptors, Cell Surface/metabolism
OTO - NOTNLM
OT  - CD105
OT  - E-cadherin
OT  - MVD
OT  - angiogenesis
OT  - immunohistochemistry
OT  - laryngeal carcinoma
EDAT- 2023/10/03 06:47
MHDA- 2024/03/21 12:43
CRDT- 2023/10/03 05:43
PHST- 2023/08/20 00:00 [received]
PHST- 2023/09/27 00:00 [accepted]
PHST- 2023/09/25 00:00 [revised]
PHST- 2024/03/21 12:43 [medline]
PHST- 2023/10/03 06:47 [pubmed]
PHST- 2023/10/03 05:43 [entrez]
AID - VM/OJS/J/97035 [pii]
AID - 10.5603/fhc.97035 [doi]
PST - ppublish
SO  - Folia Histochem Cytobiol. 2023;61(3):183-192. doi: 10.5603/fhc.97035. Epub 2023 
      Oct 3.