PMID- 37788778
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231115
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 906
DP  - 2024 Jan 1
TI  - Essential metals modified the effects of polycyclic aromatic hydrocarbons on the 
      metabolic syndrome: Mediation effects of miRNA.
PG  - 167506
LID - S0048-9697(23)06133-8 [pii]
LID - 10.1016/j.scitotenv.2023.167506 [doi]
AB  - Metabolic syndrome (MetS) prevalence has increased dramatically worldwide and has 
      become a public health issue. Polycyclic aromatic hydrocarbons (PAHs) were 
      identified as risk factors of MetS, while essential metals are integral parts of 
      metalloenzymes catalyzing metabolic processes. However, effects of co-exposure to 
      PAHs and essential metals have not been investigated yet. We aimed to assess 
      whether essential metals could modify the hazard effects of PAHs on MetS, and 
      underlying mediation effects of microRNA (miRNAs) were further explored. A 
      cross-sectional study of 1451 males including 278 MetS cases was conducted. 
      Internal exposure levels of 5 classes of PAH metabolites, 7 essential metals, as 
      well as expressions of PAHs-associated 8 plasma miRNAs were assessed. Multiple 
      exposure models, Bayesian kernel machine regression (BKMR), and quantile 
      g-computation (QGcomp) were used simultaneously to identify MetS-related critical 
      chemicals. Mutual effect modification between chemicals and mediation effects of 
      miRNAs on chemical-MetS association was testified. In this study, 
      hydroxyphenanthrene (OHPhe) and selenium (Se) were consistently identified as 
      MetS-related key chemicals in three statistical methods. OHPhe was positively 
      associated with MetS [OR (95 % CI) = 1.79 (1.21, 2.65), P = 0.004], while Se had 
      a negative relationship with MetS [OR (95 % CI) = 0.61 (0.43, 0.87), P = 0.007]. 
      Effect modification analysis observed the association between OHPhe and MetS was 
      weakened with increased Se exposure. Only the expression of miR-24-3p was 
      negatively associated with MetS [OR (95 % CI) = 0.81 (0.66, 0.95), P = 0.048] and 
      could mediate 16.1 % of OHPhe-MetS association in subjects with low Se exposure 
      (</=0.87 mug/mmol creatinine) (P = 0.019). We found a mutual effect modification 
      between OHPhe and Se on MetS, and the positive OHPhe-MetS association was 
      attenuated with increased Se exposure. Mediation effects of miR-24-3p on 
      OHPhe-MetS association were dependent on Se dose. Our findings may provide new 
      insight into the prevention and intervention of MetS.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Deng, Qifei
AU  - Deng Q
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China.
FAU - Wei, Yanzhu
AU  - Wei Y
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China.
FAU - Liu, Kang
AU  - Liu K
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China.
FAU - Wu, Degang
AU  - Wu D
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China.
FAU - Zhu, Xinyu
AU  - Zhu X
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China.
FAU - Xu, Mengya
AU  - Xu M
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China.
FAU - Bai, Yansen
AU  - Bai Y
AD  - Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical 
      University, Xinzao, Panyu District, Guangzhou 511416, China. Electronic address: 
      baiyansen6@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231001
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (MicroRNAs)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Metals)
RN  - H6241UJ22B (Selenium)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Male
MH  - Humans
MH  - *MicroRNAs
MH  - *Metabolic Syndrome/epidemiology
MH  - *Polycyclic Aromatic Hydrocarbons/toxicity
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Metals/toxicity
MH  - *Selenium
MH  - Biomarkers
OTO - NOTNLM
OT  - Effect modification
OT  - Essential metals
OT  - Mediation effect
OT  - Metabolic syndrome
OT  - Polycyclic aromatic hydrocarbons
OT  - miRNA
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/04 00:42
MHDA- 2023/11/15 06:43
CRDT- 2023/10/03 19:14
PHST- 2023/06/28 00:00 [received]
PHST- 2023/09/25 00:00 [revised]
PHST- 2023/09/29 00:00 [accepted]
PHST- 2023/11/15 06:43 [medline]
PHST- 2023/10/04 00:42 [pubmed]
PHST- 2023/10/03 19:14 [entrez]
AID - S0048-9697(23)06133-8 [pii]
AID - 10.1016/j.scitotenv.2023.167506 [doi]
PST - ppublish
SO  - Sci Total Environ. 2024 Jan 1;906:167506. doi: 10.1016/j.scitotenv.2023.167506. 
      Epub 2023 Oct 1.