PMID- 37789740
OWN - NLM
STAT- MEDLINE
DCOM- 20231114
LR  - 20231114
IS  - 1365-2516 (Electronic)
IS  - 1351-8216 (Linking)
VI  - 29
IP  - 6
DP  - 2023 Nov
TI  - Neuroinflammatory markers in patients with haemophilia and healthy controls: 
      Where are the differences?
PG  - 1539-1546
LID - 10.1111/hae.14881 [doi]
AB  - INTRODUCTION: People with haemophilia (PwH) suffer from haemophilic arthropathy 
      which is accompanied by acute and chronic inflammation. The aim of this study was 
      to examine the neuroinflammatory network operative in PwH and to compare it to 
      healthy controls. MATERIAL AND METHODS: Blood samples were collected from 41 PwH 
      (age 54.7 +/- 11.7 years) and 33 healthy controls (age 50.9 +/- 10.5 years) and the 
      levels of 13 neuroinflammatory markers were analyzed by applying an 
      antibody-based detection kit in a flow cytometer. RESULTS: From 13 analyzed 
      markers, three-ss-nerve growth factor (ss-NGF), soluble receptor for advanced 
      glycation endproducts (sRAGE) and Interleukin-18 (IL-18) differed significantly 
      between the groups (ss-NGF p = .045; sRAGE p = .003; IL-18 p = .007). While ss-NGF 
      was downregulated in PwH, sRAGE and IL-18 were upregulated. None of the analyzed 
      markers corelated to the joint status of PwH while CCL2 (C-C motif ligand 2 
      chemokine) correlated to HIV infections in PwH (r = .313, p = .007). Correlation 
      analyses of the markers studied also revealed many differences between PwH and 
      controls suggesting a number of deregulations in PwH. CONCLUSION: The altered 
      levels of sRAGE and ss-NGF in PwH, which have not been analyzed in PwH before, may 
      help to understand the neuroinflammatory network operative in PwH. The general 
      inflammatory processes in PwH and the involved biomarkers in PwH remain poorly 
      understood. PwH could benefit from new therapies against neuroinflammation which 
      may help to reduce inflammation or also chronic pain.
CI  - (c) 2023 The Authors. Haemophilia published by John Wiley & Sons Ltd.
FAU - Wehmeier, Udo F
AU  - Wehmeier UF
AUID- ORCID: 0000-0003-1559-1731
AD  - Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
FAU - Orth, Valerie
AU  - Orth V
AD  - Department of Surgery II, HELIOS University Hospital Wuppertal, Wuppertal, 
      Germany.
FAU - Hoppe, Vanessa
AU  - Hoppe V
AD  - Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
FAU - Valentino, Leonard A
AU  - Valentino LA
AUID- ORCID: 0000-0002-7927-6418
AD  - National Haemophilia Foundation, New York City, New York, USA.
AD  - Rush University, Chicago, Illinois, USA.
FAU - Hilberg, Thomas
AU  - Hilberg T
AUID- ORCID: 0000-0002-0935-2526
AD  - Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
LA  - eng
PT  - Journal Article
DEP - 20231003
PL  - England
TA  - Haemophilia
JT  - Haemophilia : the official journal of the World Federation of Hemophilia
JID - 9442916
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - 0 (Interleukin-18)
RN  - 0 (Receptor for Advanced Glycation End Products)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - *Hemophilia A/complications
MH  - Nerve Growth Factor
MH  - Interleukin-18
MH  - *HIV Infections
MH  - Neuroinflammatory Diseases
MH  - Receptor for Advanced Glycation End Products
OTO - NOTNLM
OT  - blood samples
OT  - haemophilia
OT  - inflammation
OT  - neuroinflammatory markers
EDAT- 2023/10/04 06:43
MHDA- 2023/11/14 06:42
CRDT- 2023/10/04 03:10
PHST- 2023/09/27 00:00 [revised]
PHST- 2023/06/21 00:00 [received]
PHST- 2023/09/27 00:00 [accepted]
PHST- 2023/11/14 06:42 [medline]
PHST- 2023/10/04 06:43 [pubmed]
PHST- 2023/10/04 03:10 [entrez]
AID - 10.1111/hae.14881 [doi]
PST - ppublish
SO  - Haemophilia. 2023 Nov;29(6):1539-1546. doi: 10.1111/hae.14881. Epub 2023 Oct 3.