PMID- 37790916 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231005 IS - 1179-318X (Print) IS - 1179-318X (Electronic) IS - 1179-318X (Linking) VI - 14 DP - 2023 TI - The Effectiveness of Indigenous Knowledge-Based Lifestyle Interventions in Preventing Obesity and Type 2 Diabetes Mellitus in Indigenous Children in Canada: A Systematic Review. PG - 175-193 LID - 10.2147/AHMT.S405814 [doi] AB - BACKGROUND: Indigenous children in Canada have high rates of obesity and type 2 diabetes mellitus (T2DM). Culturally appropriate interventions, guided by an Indigenous knowledge-based view of health, are crucial to target these conditions. The objective of this systematic review was to assess the impact of indigenous Knowledge-based lifestyle interventions on the prevention of obesity and T2DM in Indigenous children in Canada. METHODS: Database searches were conducted from inception until February 22, 2022. The main outcomes were changes in Body Mass Index (BMI) z-score and the development of T2DM. The other outcomes included adiposity, metabolic, and lifestyle determinants of health. The GRADE approach was used to assess confidence in the evidence. RESULTS: Four non-randomized controlled trials (non-RCTs) and six uncontrolled studies were identified. Peer-led interventions led to a reduction in BMI z-score and waist circumference. GRADE assessment revealed very low quality of evidence due to a lack of randomization and small sample sizes. There were no diabetes-specific reported programs. CONCLUSION: Limited evidence from non-randomized studies suggest that peer-led indigenous Knowledge-based lifestyle interventions improve BMI z-score and central adiposity. There is a need for community-owned and adequately powered randomized studies for interventions that aim to treat and prevent obesity and T2DM in Indigenous children in Canada. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017072781. CI - (c) 2023 Kshatriya et al. FAU - Kshatriya, Maya AU - Kshatriya M AUID- ORCID: 0000-0002-0375-1251 AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Global Health Graduate Program, McMaster University, Hamilton, Ontario, Canada. FAU - Wang, Kuan-Wen AU - Wang KW AUID- ORCID: 0000-0002-4208-2046 AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Hildebrand, Julia AU - Hildebrand J AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Crawford, Rebecca AU - Crawford R AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Indigenous Undergraduate Summer Research Program, McMaster University, Hamilton, Ontario, Canada. FAU - Nadarajah, Ajantha AU - Nadarajah A AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Global Health Graduate Program, McMaster University, Hamilton, Ontario, Canada. FAU - Youssef, Michael AU - Youssef M AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Rivas, Angelica AU - Rivas A AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Michael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada. FAU - Kaushal, Ashleen AU - Kaushal A AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. FAU - Banfield, Laura E AU - Banfield LE AUID- ORCID: 0000-0001-6123-1476 AD - Health Sciences Library, McMaster University, Hamilton, Ontario, Canada. FAU - Thabane, Lehana AU - Thabane L AD - Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. AD - Biostatistics Unit, St. Joseph's Healthcare-Hamilton, Hamilton, Ontario, Canada. AD - Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada. AD - Centre for Evaluation of Medicines, St. Joseph's Health Care, Hamilton, Ontario, Canada. FAU - Samaan, M Constantine AU - Samaan MC AUID- ORCID: 0000-0002-6403-4715 AD - Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. AD - Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. AD - Global Health Graduate Program, McMaster University, Hamilton, Ontario, Canada. AD - Michael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada. AD - Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. LA - eng PT - Journal Article PT - Review DEP - 20230928 PL - New Zealand TA - Adolesc Health Med Ther JT - Adolescent health, medicine and therapeutics JID - 101576821 PMC - PMC10544169 OTO - NOTNLM OT - child OT - diabetes OT - ethnicity OT - obesity OT - prevention COIS- The authors declare no competing interests. EDAT- 2023/10/04 06:44 MHDA- 2023/10/04 06:45 PMCR- 2023/09/28 CRDT- 2023/10/04 04:13 PHST- 2023/02/14 00:00 [received] PHST- 2023/09/20 00:00 [accepted] PHST- 2023/10/04 06:45 [medline] PHST- 2023/10/04 06:44 [pubmed] PHST- 2023/10/04 04:13 [entrez] PHST- 2023/09/28 00:00 [pmc-release] AID - 405814 [pii] AID - 10.2147/AHMT.S405814 [doi] PST - epublish SO - Adolesc Health Med Ther. 2023 Sep 28;14:175-193. doi: 10.2147/AHMT.S405814. eCollection 2023.