PMID- 37791422
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231024
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 11
IP  - 40
DP  - 2023 Oct 18
TI  - Polyprodrugs for tumor chemotherapy: from molecular structure to drug release 
      performance.
PG  - 9565-9571
LID - 10.1039/d3tb01700a [doi]
AB  - Polyprodrugs have been recognized as promising carrier-free drug delivery systems 
      (DDSs) for tumor chemotherapy in recent years, showing distinct superiority in 
      comparison with the conventional polymer prodrugs. In the present work, the 
      structure-property relationship of polyprodrugs was explored from the perspective 
      of molecular structure, by discussing the effects of the conjugations and linkers 
      on their drug content and drug releasing performance, including drug releasing 
      rate and drug releasing selectivity, as well as the anti-tumor performance of the 
      released drugs. Moreover, the future challenges in the design of 
      polyprodrug-based DDSs with high anti-tumor efficacy were also highlighted.
FAU - Liu, Peng
AU  - Liu P
AUID- ORCID: 0000-0003-1198-4925
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of 
      China. pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231018
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Prodrugs)
SB  - IM
MH  - Humans
MH  - *Antineoplastic Agents/chemistry
MH  - Drug Liberation
MH  - Molecular Structure
MH  - Drug Delivery Systems
MH  - *Prodrugs/chemistry
MH  - *Neoplasms/drug therapy
EDAT- 2023/10/04 06:43
MHDA- 2023/10/23 01:18
CRDT- 2023/10/04 04:23
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/04 06:43 [pubmed]
PHST- 2023/10/04 04:23 [entrez]
AID - 10.1039/d3tb01700a [doi]
PST - epublish
SO  - J Mater Chem B. 2023 Oct 18;11(40):9565-9571. doi: 10.1039/d3tb01700a.