PMID- 37792965
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240210
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 47
IP  - 1
DP  - 2024 Jan 11
TI  - Circadian misalignment impacts the association of visceral adiposity with 
      metabolic syndrome in adolescents.
LID - 10.1093/sleep/zsad262 [doi]
LID - zsad262
AB  - STUDY OBJECTIVES: Although insufficient sleep is a risk factor for metabolic 
      syndrome (MetS), the circadian timing of sleep (CTS) is also involved in cardiac 
      and metabolic regulation. We examined whether delays and deviations in the sleep 
      midpoint (SM), a measure of CTS, modify the association between visceral adipose 
      tissue (VAT) and MetS in adolescents. METHODS: We evaluated 277 adolescents 
      (median 16 years) who had at least 5 nights of at-home actigraphy (ACT), in-lab 
      polysomnography (PSG), dual-energy X-ray absorptiometry (DXA) scan, and MetS 
      score data. Sleep midpoint (SM), sleep irregularity (SI), and social jetlag (SJL) 
      were examined as effect modifiers of the association between VAT and MetS, 
      including waist circumference, blood pressure, insulin resistance, triglycerides, 
      and cholesterol. Linear regression models adjusted for demographics, ACT-sleep 
      duration, ACT-sleep variability, and PSG-apnea-hypopnea index. RESULTS: The 
      association between VAT and MetS was significantly stronger (p-values for 
      interactions < 0.001) among adolescents with a schooldays SM later than 4:00 
      (2.66 [0.30] points increase in MetS score), a SI higher than 1 hour (2.49 
      [0.30]) or a SJL greater than 1.5 hours (2.15 [0.36]), than in those with an 
      earlier SM (<3:00; 1.76 [0.28]), lower SI (<30 minutes; 0.98 [0.70]), or optimal 
      SJL (<30 minutes; 1.08 [0.45]). CONCLUSIONS: A delayed sleep phase, an irregular 
      sleep-wake cycle, and greater social jetlag on schooldays identified adolescents 
      in whom VAT had a stronger association with MetS. Circadian misalignment is a 
      risk factor that enhances the impact of visceral obesity on cardiometabolic 
      morbidity and should be a target of preventative strategies in adolescents.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of Sleep 
      Research Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Morales-Ghinaglia, Natasha
AU  - Morales-Ghinaglia N
AUID- ORCID: 0000-0002-5312-2509
AD  - Sleep Research and Treatment Center, College of Medicine, Department of 
      Psychiatry and Behavioral Health, Penn State University, Hershey, PA, USA.
FAU - He, Fan
AU  - He F
AUID- ORCID: 0000-0002-4145-9999
AD  - Department of Public Health Sciences, College of Medicine, Penn State University, 
      Hershey, PA, USA.
FAU - Calhoun, Susan L
AU  - Calhoun SL
AD  - Sleep Research and Treatment Center, College of Medicine, Department of 
      Psychiatry and Behavioral Health, Penn State University, Hershey, PA, USA.
FAU - Vgontzas, Alexandros N
AU  - Vgontzas AN
AUID- ORCID: 0000-0002-8323-7526
AD  - Sleep Research and Treatment Center, College of Medicine, Department of 
      Psychiatry and Behavioral Health, Penn State University, Hershey, PA, USA.
FAU - Liao, Jason
AU  - Liao J
AD  - Department of Public Health Sciences, College of Medicine, Penn State University, 
      Hershey, PA, USA.
FAU - Liao, Duanping
AU  - Liao D
AD  - Department of Public Health Sciences, College of Medicine, Penn State University, 
      Hershey, PA, USA.
FAU - Bixler, Edward O
AU  - Bixler EO
AD  - Sleep Research and Treatment Center, College of Medicine, Department of 
      Psychiatry and Behavioral Health, Penn State University, Hershey, PA, USA.
FAU - Fernandez-Mendoza, Julio
AU  - Fernandez-Mendoza J
AUID- ORCID: 0000-0001-9584-6161
AD  - Sleep Research and Treatment Center, College of Medicine, Department of 
      Psychiatry and Behavioral Health, Penn State University, Hershey, PA, USA.
LA  - eng
GR  - R01 HL136587/HL/NHLBI NIH HHS/United States
GR  - R01HL136587/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - *Metabolic Syndrome/complications/metabolism
MH  - Obesity, Abdominal/complications/metabolism
MH  - Adiposity/physiology
MH  - *Insulin Resistance/physiology
MH  - Risk Factors
MH  - Sleep/physiology
MH  - Jet Lag Syndrome
PMC - PMC10782492
OTO - NOTNLM
OT  - adolescents
OT  - circadian rhythms
OT  - metabolic disease
OT  - obesity
EDAT- 2023/10/04 18:42
MHDA- 2024/01/12 06:42
PMCR- 2024/10/04
CRDT- 2023/10/04 14:13
PHST- 2023/08/02 00:00 [received]
PHST- 2023/09/08 00:00 [revised]
PHST- 2024/10/04 00:00 [pmc-release]
PHST- 2024/01/12 06:42 [medline]
PHST- 2023/10/04 18:42 [pubmed]
PHST- 2023/10/04 14:13 [entrez]
AID - 7288965 [pii]
AID - zsad262 [pii]
AID - 10.1093/sleep/zsad262 [doi]
PST - ppublish
SO  - Sleep. 2024 Jan 11;47(1):zsad262. doi: 10.1093/sleep/zsad262.