PMID- 37794445
OWN - NLM
STAT- MEDLINE
DCOM- 20231006
LR  - 20231121
IS  - 1757-1146 (Electronic)
IS  - 1757-1146 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Oct 5
TI  - Association between triglyceride glucose index and severity of diabetic foot 
      ulcers in type 2 diabetes mellitus.
PG  - 68
LID - 10.1186/s13047-023-00663-7 [doi]
LID - 68
AB  - BACKGROUND: Triglyceride glucose (TyG) index is a good surrogate biomarker to 
      evaluate insulin resistance (IR). The study aimed to investigate whether the TyG 
      index is related to the severity of diabetic foot ulcers (DFUs) in patients with 
      type 2 diabetes mellitus (T2DM). METHODS: A total of 1059 T2DM patients were 
      enrolled in this observational, retrospective, single-center study. TyG index was 
      calculated as ln[fasting triglycerides (mg/dl) x fasting glucose (mg/ dl)/2]. The 
      severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade 
      score < 3) and severe DFUs (Wagner grade score >/= 3) based on Wagner 
      classification. Patients were stratified according to the tertiles of TyG index. 
      Logistic regression models were implemented to explore the association between 
      TyG index and the severity of DFUs. Subgroup analyses were used to verify the 
      reliability of results. RESULTS: Compared with the reference lowest TyG tertile 
      (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of 
      prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 
      1.017-1.865) (P = 0.039). After adjusting for potential confounders, the 
      multivariable-adjusted OR and 95% CI were 1.506 (1.079-2.103) (P = 0.016) in 
      patients with highest tertile. Moreover, subgroup analyses indicated that the 
      association was stronger among men, patients with age >/= 65 years, duration of 
      diabetes more than 10 years, or without PAD. CONCLUSIONS: Elevated TyG index is 
      independently associated with severity of DFUs even after adjusting conventional 
      confounders.
CI  - (c) 2023. The College of Podiatry and the Australasian Podiatry Council.
FAU - Chen, Weihao
AU  - Chen W
AD  - Department of Burn and Wound Center, The First Affiliated Hospital of Wenzhou 
      Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China.
FAU - Wang, Xuedong
AU  - Wang X
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Wenzhou Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China.
FAU - Jiang, Qilin
AU  - Jiang Q
AD  - Department of Burn and Wound Center, The First Affiliated Hospital of Wenzhou 
      Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China.
FAU - Wu, Jiyan
AU  - Wu J
AD  - Department of Burn and Wound Center, The First Affiliated Hospital of Wenzhou 
      Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China.
FAU - Shi, Wanyan
AU  - Shi W
AD  - Department of Internal Medicine, Taishun County Hospital of Traditional Chinese 
      Medicine, Wenzhou, Zhejiang, China.
FAU - Wang, Xiaoxiao
AU  - Wang X
AD  - Department of Endocrine, Wencheng People's Hospital, Wenzhou, Zhejiang, China.
FAU - Yin, Yihu
AU  - Yin Y
AD  - Department of Burn and Wound Center, The First Affiliated Hospital of Wenzhou 
      Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China.
FAU - Zheng, Jiayin
AU  - Zheng J
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang, China.
FAU - Hu, Xiang
AU  - Hu X
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Wenzhou Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China. 
      huxiang@wmu.edu.cn.
FAU - Lin, Cai
AU  - Lin C
AD  - Department of Burn and Wound Center, The First Affiliated Hospital of Wenzhou 
      Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China. 
      13025092850@163.com.
FAU - Zhang, Xingxing
AU  - Zhang X
AUID- ORCID: 0000-0002-1460-1865
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Wenzhou Medical University, Shangcai Village, Wenzhou, 325000, Zhejiang, China. 
      Zhangxingxing@wzhospital.cn.
LA  - eng
GR  - ZJ2021-LD002/Zhejiang Wound Repair and Transformation Application project/
GR  - Y2020236/Science and Technology Plan Project of Wenzhou, China/
GR  - LGD22H070001/Natural Science Foundation of Zhejiang Province/
PT  - Journal Article
PT  - Observational Study
DEP - 20231005
PL  - England
TA  - J Foot Ankle Res
JT  - Journal of foot and ankle research
JID - 101471610
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - Glucose
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Risk Factors
MH  - Retrospective Studies
MH  - Blood Glucose
MH  - *Diabetic Foot
MH  - Triglycerides
MH  - Reproducibility of Results
PMC - PMC10552301
OTO - NOTNLM
OT  - Chronic wounds
OT  - Diabetic foot ulcer
OT  - Triglyceride glucose index
COIS- The authors declare that they have no competing interests.
EDAT- 2023/10/05 01:00
MHDA- 2023/10/06 06:43
PMCR- 2023/10/05
CRDT- 2023/10/04 23:45
PHST- 2023/04/14 00:00 [received]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/10/06 06:43 [medline]
PHST- 2023/10/05 01:00 [pubmed]
PHST- 2023/10/04 23:45 [entrez]
PHST- 2023/10/05 00:00 [pmc-release]
AID - 10.1186/s13047-023-00663-7 [pii]
AID - 663 [pii]
AID - 10.1186/s13047-023-00663-7 [doi]
PST - epublish
SO  - J Foot Ankle Res. 2023 Oct 5;16(1):68. doi: 10.1186/s13047-023-00663-7.