PMID- 3779445 OWN - NLM STAT- MEDLINE DCOM- 19870115 LR - 20190614 IS - 0006-8993 (Print) IS - 0006-8993 (Linking) VI - 395 IP - 2 DP - 1986 Dec TI - Effects of sex steroids on the development of two granule cell subpopulations in the rat accessory olfactory bulb. PG - 283-6 AB - The effects of postnatal male castration on day 1 (D1) after birth and female androgenization on accessory olfactory bulb (AOB) light and dark granule cell populations were studied. Control males showed a greater number of both light and dark AOB granule cells than females. Postnatal treatment reversed these differences in the light granule cells. Female androgenization on D1 does not affect the number of AOB dark granule cells. However, male orchidectomy also on D1 significantly decreases the number of dark granule cells. Androgens injected into female rats are able to increase the number of AOB dark granule cells if they are administered on D14. This suggests a different critical period for the early effects of androgens on the dark granule cells with respect to light granule cells. FAU - Segovia, S AU - Segovia S FAU - Valencia, A AU - Valencia A FAU - Cales, J M AU - Cales JM FAU - Guillamon, A AU - Guillamon A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 RN - 0 (Gonadal Steroid Hormones) RN - 3XMK78S47O (Testosterone) SB - IM MH - Animals MH - Cell Differentiation MH - Female MH - Gonadal Steroid Hormones/*physiology MH - Male MH - Olfactory Bulb/cytology/drug effects/*growth & development MH - Orchiectomy MH - Rats MH - Sex Characteristics MH - Testosterone/pharmacology EDAT- 1986/12/01 00:00 MHDA- 1986/12/01 00:01 CRDT- 1986/12/01 00:00 PHST- 1986/12/01 00:00 [pubmed] PHST- 1986/12/01 00:01 [medline] PHST- 1986/12/01 00:00 [entrez] AID - S0006-8993(86)80209-8 [pii] AID - 10.1016/s0006-8993(86)80209-8 [doi] PST - ppublish SO - Brain Res. 1986 Dec;395(2):283-6. doi: 10.1016/s0006-8993(86)80209-8.